Hedgehog signaling is reactivated in various types of cancer, and this contributes to cancer progression by facilitating proliferation, invasion and cell survival. Moreover, Hh signaling is associated with several other signaling pathways that contribute to cancer progression. These observations indicate ...
1, bottom panels) shows that co-localization is variable from cell to cell as well as in different contiguous membrane regions of the same adipocyte. Some cells had no appreciable GLUT4 plasma membrane residence (Fig. 1, white arrow) whereas other cells showed stop-start regions of overlap ...
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Intracellular signaling pathways: tyrosine kinase and mTOR inhibitors) Clin Microbiol Infect, 24 (2018), pp. S53-S70 View in Scopu...
we used scRNA-seq to analyze the consequences of epithelial cell type-specific depletion through inducible expression of diphtheria toxin subunit A (DTA) in the mouse distal lung, which has the
Certain morphological, physiological and molecular characteristics are shared by all neurons. However, despite these similarities, neurons constitute the most diverse cell population of any organism. Recently, considerable attention has been focused on i
In vivo and in vitro analyses indicated that genistein can modulate numerous signaling cascades in several types of cancer cells, that results in decreased cell viability, and promotion of cell death [5]. Figure 1 illustrates the molecular interactions of genistein in different cellular pathways. ...
Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated into cellular signaling pathways are not yet understood. Herein, we report the cellular res...
More genes and pathways were altered in MSCs than in ADSCs. These changes may be responsible for the differences in the adipogenesis potential of ADSCs and MSCs after MSTN treatment. Analysis of the functions of genes that are differentially expressed in ADSCs and MSCs showed that KLF6 is a ...
Conclusions The easy, cost-effective workflow makes automated CUT&RUN an attractive tool for high-throughput characterization of cell types and patient samples.Background Cells establish their distinct identities by altering activity of the cis-regulatory DNA elements that control gene expression [1, 2...
Prostate tumor heterogeneity is a major factor in disease management. Heterogeneity could be due to multiple cancer cell types with distinct gene expression. Of clinical importance is the so-called cancer stem cell type. Cell type-specific transcriptomes