Type II beta-Turn Formation in Tetrapeptides Evidenced by Vibrational Circular Dichroism SpectroscopyThe vibrational circular dichroism (VCD) features of P-turns were studied previously in cyclic peptides, although a complete set of rules for their characterization has not yet been given. The model ...
(1993) The evaluation of type I and Type II beta-turn mixtures. Circular dichroism, NMR and molecular dynamics studies. Int. J. Pept. Protein Res. 41, 223±236.Perczel, A., Hollosi, M., Sandor, P., and Fasman, G. D. (1993) The evaluation of type I and type II β-turn ...
The structural determinants of type II' beta-turns were probed through a comprehensive CD, NMR, and molecular dynamics analysis of 10 specially designed beta-hairpin peptides. The peptide model used in this study is a synthetic, water-soluble, 14-residue cyclic analogue of gramicidin S which con...
The two most important beta-turn features in peptides and proteins are the type I and type II turns, which differ mainly in the orientation of the central ... K Gunasekaran,L Gomathi,C Ramakrishnan,... - 《Journal of Molecular Biology》 被引量: 171发表: 1998年 Effect of a Diphosphonate...
Broken beta cells.If the cells that make insulin send it out at the wrong time, your blood sugar gets thrown off.High blood sugarcan damage these cells, too. Type 2 Diabetes Risk Factors Certain things make it more likely that you’ll get type 2 diabetes. The more of these factors appl...
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia 53, 321–330 (2010). This study modelled lipofuscin accumulation in human β-cells with age; together with the complementary methods used in reference 84, this ...
In addition to the cell therapy programmes, for example, it is also working with CRISPR Therapeutics on CTX001, a gene-editing therapy for beta thalassemia and sickle cell disease. “We have never been in more disease areas than we are right now. We have never used more modalities in the...
Type II phosphatidylinositol (PtdIns) 4-kinases produce PtdIns 4-phosphate, an early key signaling molecule in phosphatidylinositol cycle, which is indispensable for T cell activation. Type II PtdIns 4- kinase alpha and beta have similar biochemical properties. To distinguish these isoforms Epigallocatech...
Protein β-turn mimetics II: Design, synthesis, and evaluation in the cyclic peptide gramicidin S The benzodiazepine (BZD) peptidomimetic I has been substituted for the naturally occurring four amino acid beta-turn in a Gramicidin S analog, cyclo-(Lys-Leu-dPhe-Val)2 and shown by NMR structura...
[1], the low to no expression of MHC II by brain-resident microglial cells during homeostasis, the absence of other antigen-presenting cells, and the presence of a blood−brain barrier that prevents immune-cell recruitment inside the brain led to and supported the notion that the brain is ...