CONCLUSIONS: Failure of isoflurane cardiac preconditioning in obese type II diabetic db/db mice is associated with aberrant regulation of microRNA-21, endothelial nitric-oxide synthase, and mitochondrial respiratory complex I. 展开 DOI: 10.1097/ALN.0000000000001926 被引量: 3 ...
Typically, the immune response to RSV is a type 1 response that involves both the innate and adaptive immune systems. However, type 2 cytokines may also be produced as a result of infection of RSV and there is increasing evidence that children who develop severe RSV-associated bronchiolitis are...
Its efficacy in reducing seasonal exacerbations, triggered by respiratory viruses, has also been reported. The mechanism, not yet fully understood, probably involves the restoration of antiviral defences (for example, type I interferon production) [43]. ...
Type II Diabetes involves the development of insulin resistance (i.e. a dampening of the metabolic response to insulin). What would the likely metabolic effects be of a person being hypersensitive to insulin? Type 1 and type 2 diabetes mellitus both result ...
In this context, it is important to highlight the concept of mitochondrial hormesis in type 2 diabetes [10], which involves a reduction of ROS production and ATP synthesis in different tissues in response to high levels of glucose or excess of nutrient intake, constituting a compensatory response...
The largest group of “cytotoxic” hypersensitivity reactions involves the hematologic diseases, with antibodies directed against antigens present on the surface of red blood cells and platelets. Type II hypersensitivity reactions are mediated by antibodies directed against antigens on the surface of ...
Another method involves the recombinant enzyme and the corresponding antibody to form fusion proteins, which are targeted to bind the insulin receptor or transferrin receptor and facilitate the entry of the recombinant enzyme into the BBB through receptor-mediated endocytosis [79]. A phase 1/2 ...
The pathogenesis of type 2 diabetes involves inadequate insulin secretion and resistance to the action of insulin. Suggestive data link insulin resistance and accompanying hyperglycemia to an excess of abdominal adipose tissue, a link that appears to be mediated partially by adipocyte secretion of ...
Once this aim has been achieved, the last stage of the inflammatory response involves the restoration of the tissue to its original state. Clearly, the recruitment and tissue-reparative stages must be closely regulated in the lung because excessive tissue injury or overexuberant tissue healing can ...
The two frameshift mutations were found in compound heterozygous form in case 2, and the c.228_229insC mutation in homozygous form in the severely hydropic fetus of case 3. The third mutation, found homozygously in the case with parental consanguinity, involves Asp112, an amino acid that ...