A substantial increase in colorectal cancer (CRC)鈥揳ssociated fatalities can be attributed to tumor recurrence and multidrug resistance. Traditional treatment options, including radio- and chemotherapy, also exhibit adverse side effects. Ancient treatment strategies that include phyto...
In stem cells, MYC regulates a wide range of both protein-coding and non-coding genes as well as various biological functions like cell differentiation, metabolism, and self-renewal [25]. A well-known transcription factor called MYC promotes somatic cell proliferation effectively, and this property...
Emerging evidence suggests that constitutive activation of Nrf2 (Fig.1C) promotes the expression of genes involved in drug metabolism, thereby imparting resistance to foreign chemotherapeutic agents and allowing cell survival [56]. Also, Nrf2 supports cell proliferation by inducing metabolic reprogramming ...
Autophagy has been identified as a key player in cancer therapeutic resistance. By enabling cells to survive and adapt under adverse conditions induced by therapeutic agents, autophagy serves as a double-edged sword, both promoting cell survival and potentially contributing to treatment resistance [13,...
Tumor microenvironment (TME) is composed of diverse cell types whose interactions, both direct and indirect, significantly influence tumorigenesis and ther
senescence);cTXNIP mediates drug-induced cell death via ROS-dependent/- independent pathways;dTXNIP impacts on cellular metabolism, transforming cells from glycolytic to reliant on oxidative phosphorylation, by regulating the expression of GLUT1/4;eTXNIP increases the expression of VEGFA, PDGF, and ...
survival and migration. Thus, cAMP has pleiotropic effects on both physiological and pathophysiological processes, such as development, reproduction, angiogenesis, cell cycle progression, insulin secretion, energy metabolism, and pluripotent stem cell reprogramming. Besides, nuclear cAMP signaling is important...
mediating tumor metabolism and accelerating the progression of HCC [139]. Although it is not the scope of current review, but it is worth mentioning that exosomes can be engineered in laboratory for purpose of cancer therapy and such approach has been followed in HCC treatment. PIONs-contained ...
Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients. Curr Drug Metab. 12:918–31. Mao L, Li Y, Zhao J, Li Q, Yang B, Wang Y, et al. Transforming growth factor-β1 contributes to oxaliplatin resistance in colorectal ...
Beyond which, hypoxic microenvironment around the growing tumors activates angiogenic network via upregulation of hypoxia-inducible transcription factor, which triggers various specific transcriptional responses such as cell division, metabolism, and angiogenesis [36]. Furthermore, angiogenic switch is ...