摘要:阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病。大量证据表明,遗传因素在AD的发病机制中起重要作用。2型髓系细胞触发受体(triggering receptor expressed on myeloid cells 2,TREM2)基因是新发现的AD易感基因之一。文章搜索近年来相关高质量文献,结合课题组前期成果,从TREM2基因变异与AD易感...
Alzheimer's disease (AD) was first described more than a century ago by the German neuropsychiatrist, Dr. Alois Alzheimer ([1], English translation [2]), and today is the leading cause of dementia worldwide [3,4,5]. In the United States, deaths attributed to AD have increased by 71%...
Recent research has shown that the triggering receptor expressed on myeloid cells 2 (TREM2) in microglia is closely related to the pathogenesis of Alzheimer’s disease (AD). The mechanism of this relationship, however, remains unclear. TREM2 is part of the TREM family of receptors, which are...
Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a complex neurodegenerative disease marked by the appearance of amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles. Alzheimer's disease has a strong genetic component and recent advances in genome technology...
We then assayed the expression of TREM2 across different regions of the human brain and identified genes that are differentially expressed in a mouse model of Alzheimer's disease and in control mice. RESULTS: We found significantly more variants in exon 2 of TREM2 in patients with Alzheimer's...
Plasma soluble TREM2 and inflammatory markers in Alzheimer's disease TREM2 genetic variants have been shown to increase risk for AD and other neurodegenerative disorders. Leukocyte TREM2 mRNA has been described as elevated in AD. However, the cleaved, soluble protein (sTREM2) is not elevated in...
TREM2: A Novel Potential Biomarker of Alzheimer’s Disease ZHANG Xiao Min1, & , LIU Jing1, & , CAO Min1 , YANG Ting Ting2 , WANG Ya Qi1 , HOU Yu Li1 , SONG Qiao1 , CUI Yu Ting1 , WANG Pei Chang1 , , 1. Department of Clinical Laboratory, Xuanwu Hospital, ...
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed on the surface of microglia. It mediates multiple pathophysiological processes in various diseases. Recently, TREM2 has been found to play a role in the development of Alzheimer’s disease (AD). TREM2 is a...
TREM2 encodes for triggering receptor expressed on myeloid cells 2 and has rare, coding variants that associate with risk for late-onset Alzheimer’s disease (LOAD) in Caucasians of European and North-American origin. This study evaluated the role of TREM2 in LOAD risk in African-American (AA...
Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary tangles. Familial AD typically results from mutations in the genes