pooled. Ricin, 10 mg in 1.4 ml of PBS was mixed with 39 μl of dimethylformamide containing 0.15 mg of the bifunctional cross-linking agent, m-maleimidobenzoyl-N-hydroxysuccinimidyl (MBS) ester (Pierce Chemical Co.). The mixture was incubated at room temperature for 30 minutes. Ricin-MBS ...
aTargeted high-throughput sequencing of off-target sites in edited (RNP) or electroporated-only (Mock) HSPCs (n = 2 experiments from two different donors; no significant difference between RNP and Mock samples when pooled and analysed with two-tailed paired Student’sttest).bSequences of...
doi:10.1016/j.electacta.2019.01.153Karan SahniMaziar AshuriQianran HeRitu SahoreLeon L. ShawElsevier ScienceElectrochimica Acta
Monkeypox, an endemic disease in both West and Central Africa, before 2022 outbreak, a few cases were reported outside of Africa and these were associated with imports from endemic countries.1,2,3,4,5However, following the initial case diagnosed in the United Kingdom, the number of monkeypo...
Epstein, Leon GMelinaldana, HectorCurran, John GMiller, Michael LBitter KJ, Epstein LG, Melin-Aldana H, et al. Cyclophosphamide treatment of primary angiitis of the central nervous system in chil- dren: report of 2 cases. J Rheumatol. 2006;33:2078-2080....
and 2 had progressed disease. The median progression-free survival was 7.13 months, with a median overall survival of 15.63 months [60]. This study showed that the non-viral piggyBac transposon system-engineered EGFR-CAR T-cell therapy is feasible and safe in the treatment of EGFR-po...
field re-stings, and the patient clinical data (clinical history, biomarkers, and skin prick test). Results: A total of 108 patients were included. In total, 4 protocols were used (5 weeks reaching 200 μg, and 4, 3, and 2 weeks reaching 100 μg). An incidence of systemic adverse ...
Hence, there is an urgent need to discover effective, safe, and affordable therapeutic options. The genome of OROV is composed of three distinct segments: large (L), medium (M), and small (S). The L segment carries the genetic information for essential proteins involved in viral replication...
and were told that no aspect of it would be painful. The caregiver remained in the room during the first two tasks administered, the second being the CVLT-II (California Verbal Learning Test-II). The caregiver sat in a corner of the room and did not engage with the participant during ...
Martin B. Leon MDLenox Hill Heart and Vascular Institute of New YorkValavanur Subramanian MDLenox Hill Heart and Vascular Institute of New YorkJeffrey W. Moses MDLenox Hill Heart and Vascular Institute of New YorkCatheterization and Cardiovascular Interventions...