Mantle cell lymphoma (MCL) primarily affects older adults, accounting for 3-10% of all non-Hodgkin lymphoma (NHL) in western countries. The disease course of MCL is heterogenous; driven by clinical, cytogenetics, and molecular features that shape differences in outcomes, including proliferation ...
Mantle cell lymphoma (MCL) predominantly affects older adults, with a median age at diagnosis of 70 years. A frequently aggressive yet incurable lymphoma, the goal of therapy for MCL is to turn a potentially life-threatening illness into a chronic disease with prolonged periods of remission. Larg...
Witzig TE. Current treatment approaches for mantle-cell lym- phoma. J Clin Oncol 2005;23(26):6409-14.Witzig TE. Current treatment approaches for mantle-cell lymphoma. J Clin Oncol. 2005; 23 :6409–6414.Witzig TE. Current treatment approaches for mantle-cell lymphoma - Review. Journal of...
Andre Goy, MD, MS, chief, Division of Lymphoma, chairman and director, John Theurer Cancer Center, discusses the evolution of treatment in mantle cell lymphoma (MCL). Physicians have made significant progress in the treatment of patients with MCL, says Goy, but states that there is a ...
Peter Martin, MD, chief of the Lymphoma Program at the Meyer Cancer Center and an associate professor of medicine at Weill Cornell Medicine, discusses treatment considerations for patients with mantle cell lymphoma (MCL). Historically, patients with MCL have been divided into 2 groups based on age...
NF-κB is a transcription factor family that regulates the growth and survival of B cells; mantle cell lymphoma cells depend on NF-κB signaling for continued growth and proliferation. The NF-κB signaling pathways are categorized into canonical and non-canonical types, wherein the canonical ...
In conclusion, the high response rate associated with the CF regimen merits further investigation in previously untreated patients with MCL, particularly in those who are not candidates for aggressive therapy. 展开 关键词: mantle cell lymphoma MCL cyclophosphamide fludarabine non-Hodgkin''s lymphoma ...
Mantle cell lymphoma is a rare form of B-cell non-Hodgkin lymphoma. It is a type of blood cancer that affects white blood cells called lymphocytes.
Mantle cell lymphomas: You might get rituximab along with chemo as the first treatment for mantle cell lymphoma. You can also get rituximab as a maintenance treatment or if the lymphoma comes back. Diffuse large B-cell lymphoma: You will get rituximab along with chemo for any stage of diffuse...
scientists from Uppsala University and other Swedish universities show that people with mantle cell lymphoma who were unmarried, and those who had low educational attainment, were less often treated with a stem-cell transplantation, which may result in poorer survival. The findings...