Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B: Local RNA translation at the synapse and in disease. J Neurosci 2011, 31:16086-16093.Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD et al (2011) Local RNA...
Both processes are dependent on new protein synthesis at the synapse. Here, we describe a mechanism how dendritic mRNAs are transported and subsequently translated at activated synapses. Furthermore, we present the players involved in the regulation of local dendritic translation upon neuronal ...
Phosphorylation of FMRP appears to be the potential switch for NMDAR mediated translation and in the absence of FMRP, the distinct translation response to NMDAR stimulation is lost. Thus, FMRP and MOV10 have an important regulatory role in NMDAR mediated translation at the synapse.Electronic ...
The brain receives its blood supply mainly through the internal carotid arteries and the...doi:10.1016/j.jalz.2014.07.028Shaw, EishaAhmad, FarazRavindranath, VijaylakshmiElsevier Inc.Alzheimers & Dementia
SynapsemTOR pathwayModelingComplex dynamicsBackground: The key role in the dynamic regulation of synaptic protein turnover belongs to the Fragile X Mental Retardation Protein, which regulates the efficiency of dendritic mRNA translation in response to stimulation of metabotropic glutamate receptors at ...
Weiler IJ, Childers WS, Greenough WT. Calcium ion impedes translation initiation at the synapse. J Neurochem. 1996; 66(1): 197-202. PMID: 8522953Weiler IJ, Childers WS, Greenough WT (1996) Calcium ion impedes translation initiation at the synapse. J Neurochem 66:197–202Weiler IJ, Childers...
Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic CleavageNeuroliginsFMRPLocal translationSynapseFragile X syndromeProteolysisNeuroligins (NLGNs) are cell adhesion molecules located on the postsynaptic side of the synapse that interact with their...
Worley P.Making proteins at the synapse: activity-regulated translation and CPEB. Neuron . 1998Making proteins at the synapse: activity-regulated translation and CPEB. Worley P. Neuron . 1998Worley P (1998) Making proteins at the synapse: activity-regulated translation and CPEB. Neuron 21:936 -...