【Conclusion】Five isoforms with complete CDS region of the TNNT3 gene were obtained in goat muscles. The sequence and expression of TNNT3 were highly conserved in mammals and enriched in muscles, indicating that potentially TNNT3 gene functions critically in muscle growth and development. Key ...
Objective:TostudythetroponinTNNT3(R69H)geneexpressionandtissuestructurechangeoffast skeletalmuscleinTNNT3mutationtransgenicmouse.Methods:TheheterozygoticTNNT3mutationtransgenic mousewasmatedwithsamebroodheterozygoticmouse.ThepositiveprogenywasdetectedbywildC57BL/6Jmouse. ...
Collectively, these findings suggest that troponins are expressed in smooth muscle and are required for normal growth and breathing for postnatal survival. Moreover, future studies with this mouse model can explore TnnT3 function in adult muscle function using the conditional-inducible gene deletion ...
There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; als Protein Expression Fetal skeletal muscle,Liver,Lung,Skeletal muscle, Subcellular Localization ...
Analysis of relative gene expression 20 期 陈媛等:山羊 TNNT3 基因可变剪切及其对骨骼肌细胞分化的作用 4477 data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 2001,25(4): 402-408. [25] MEDFORD R M, NGUYEN H T, DESTREE A T, SUMMERS E, NADAL-GINARD ...
FSHD is considered an autosomal dominant disease with incomplete penetrance and unpredictable variability of clinical expression within families. Mice overexpressing FRG1 (FSHD region gene 1), a candidate gene for this disease, develop a progressive myopathy with features of the human disorder. Here, ...
FSHD is considered an autosomal dominant disease with incomplete penetrance and unpredictable variability of clinical expression within families. Mice overexpressing FRG1 (FSHD region gene 1), a candidate gene for this disease, develop a progressive myopathy with features of the human disorder. Here, ...
Thus, we show here that HIRA has locus-specific effects on gene expression and that histone chaperone activity is vital for normal heart development, impinging on pathways regulated by an established cardiac transcription factor.Daniel DilgRasha Noureldin M. Saleh...