Previous studies have shown that tumor necrosis factor-alpha (TNF-伪) induces neuroprotection against excitotoxic damage in primary cortical neurons via sustained nuclear factor-kappa B (NF-魏B) activation. The transcription factor NF-魏B can regulate the expression of small conductance calcium-activat...
Virtually all TNF-伪-inducible genes were dependent on I魏B kinase 2 (IKK2)/NF-魏B activation, whereas a minor number was additionally modulated by p38. Furthermore, genes suppressed by IKK2/NF-魏B were newly identified. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and...