TNF-α介导的信号传导主要通过两个结构不同的受体进行：1型受体（TNFR1,又称作p60,p55,CD120a）和2型受体（TNFR2,又称作p80,p75,CD120b）。两种受体都是跨膜的糖蛋白，膜外N端区域具有多个半光 氨酸丰富的重复序列。虽然这两种受体的膜外部分有结构和功能上的同源性，但期 细胞膜内部分却完全不...
Interleukin-1alpha (IL-1alpha), IL-1beta and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in vivo around the materials, in sham operated sites, and after ex vivo incubation of surface adherent cells. Ti and Cu revealed distinct cytokine expression patterns. Cu recruited ...
that inhibit neutrophils or neutrophil-derived mediators: the major neutrophil-derived mediators are oxygen-derived free radicals, cytokines (e.g. TNF alpha and IL-1 beta), proteases (e.g. elastase), and lipid mediators (e.g. LTB4... AM Lefer,DJ Lefer - 《Annu Rev Pharmacol Toxicol》 被...
Interleukin-1 beta enhances and tumor necrosis factor-alpha inhibits bone morphogenetic protein-2-induced alkaline phosphatase activity in MC3T3-E1 osteobl... results suggest that the action of BMP on osteogenic differentiation may be regulated by such immuno/inflammatory cytokines as IL-1[beta] and...
Monoclonal antibodies (MAbs) against two non-cross-reacting antigens of human IL-1 beta (Vhp20 and BRhC3) and human TNF alpha (B154.2 and B154.7) were applied to identify cytokine-containing cells in tissue sections and in cell suspensions. IL-1 beta- or TNF alpha-positive cells were not...
The release of IL-1 beta and TNF-alpha into the medium was measured using enzyme-linked immunosorbent assays. ANOVA and Tukey multiple comparison intervals were used to compare the various experimental conditions. RESULTS: None of the metal ions elevated the IL-1 beta or TNF-alpha levels after...
Participation of COX, IL-1 beta and TNF alpha in formalin-induced inflammatory pain. 来自 Semantic Scholar 喜欢 0 阅读量: 34 作者:V Granados-Soto,R Alonso-López,R Asomoza-Espinosa,MO Rufino,SH Ferreira 摘要: METHODS: Male and female Wistar rats (weight range, 130-180 g) from our ...
Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid ...
《Betatrophin对TNFalpha或IL-1beta诱导NF-kappaB活化的负调控机制研究》是依托华中科技大学，由张煜担任项目负责人的青年科学基金项目。中文摘要 非可控炎症是糖尿病、癌症等多种重大疾病的主要诱因，调控紊乱是造成炎症处于非可控状态的重要原因。NF-kB能诱导一系列炎症相关蛋白表达，在炎症反应调控中发...