However, TNF-alpha and IL-17 are found in increased titers in lupus patients compared to the general population. Whether inhibition of these cytokines would lead to effective treatment is under discussion. In the case of anti-TNF-alpha therapies in SLE, the possibility of ATIL (anti-TNF-...
Using transcriptomic data at initiation of therapy, we identified over 100 differentially expressed genes (DEGs) that differentiated IL-17Ai response from non-response and TNFi response from non-response. Integration of cell-type-specific DEGs with protein鈥損rotein interactions and further comprehensive...
The IL23/IL17 pathway can also stimulate TNF-α activity. The pro-inflammatory cytokine IL-17 enhances the production of other pro-inflammatory cytokines including TNF-α, and the secretion IL-17 itself can be enhanced by IL-23 [6]. PAMPs can also be recognized by intracellular Nod-like re...
Int J Hyperthermia 1998;14:309 - 17.Lin JC, Park HJ, Song CW. Combined treatment of IL-1 alpha and TNF-alpha potentiates the antitumour effect of hyperthermia. Int J Hyperthermia 1996;12:335-344.Lin JC, Park HJ and Song CW (1996) Combined treatment of Il-1 α and TNF- α ...
喜达诺®的作用机制是___:A.与人白细胞介素IL-17结合B.与人白细胞介素IL-23结合C.与人白细胞介素IL-12结合D.与肿瘤坏死因子TNF-alpha结
17. Mouawad R, Antoine EC, Khayat D, Soubrane C. Effect of endogenous interleukin-6 on Fas (APO-1/CD95) receptor expression in advanced melanoma patients. Cytokines Cell Mol Ther 2000; 6: 135–140.PubMed 18. Mouawad R, Rixe O, Meric JB, Khayat D, Soubrane C. Serum interleukin-6 ...
2006. IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J. 20:E1393-E2114.Rajasingh J, Bord E, Luedemann C, Asai J, Hamada H, et al. (2006) IL-10- induced TNF-alpha mRNA ...
The bispecific fusion protein provided by the present invention includes the IL-17 receptor fragment and the TNF-α receptor fragment, can effectively bind to IL-17 and/or TNF-α, respectively and has high bioactivity, specificity and stability.Daocheng ZHU...
Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis. Mol Immunol. 2015;64(1):26-35.Amara S, Lopez K, Banan B, Brown SK, Whalen M, Myles E et al. Synergistic effect of pro-inflammatory TNFalpha and IL-17 in...
Interleukin-17Tumor necrosis factor-alphaProgrammed cell death protein 1 ligand 1Prostate cancerColon cancerProgrammed cell death protein 1 (PD-1) acts on PD-1 ligands (PD-L1 and PD-L2) to suppress activation of cytotoxic T lymphocytes. Interleukin-17 (IL-17) and tumor necrosis factor-alpha ...