Transmembrane protein 119 (TMEM119) is a cell-surface protein of unknown function, expressed exclusively by the microglia subset of myeloid and neural cells (1). Iba1+ microglia with both ramified and amoeboid morphologies express TMEM119, while Iba1+ macrophages are TMEM119 negative (2). TMEM...
因此部分研究者对TMEM119对这一工具是否能够很好的用于小胶质细胞功能的研究提出了质疑。 近日,德国Rostock大学医学中心的Hannes Kaddatz课题组在国际知名期刊GLIA上发表“Transmembrane protein 119 is neither a specific nor a reliable marker f...
(microglia,mg) 和脑边界相关巨噬细胞 (border-associated macrophages, bams; bam包括脑膜,脉络丛和血管周巨噬细胞),mg和bams都是发育早期由卵黄囊中的红系髓系祖细胞(erythromyeloid progenitor, emp)迁移到中枢神经系统并进行定殖,并通过一系列的转录因子调控最终分化为脑实质中的cd206 - 小胶质细胞与cd206 + ...
TMEM119 immunohistochemistry might provide a useful tool for investigating the biology and pathology of human microglia(PMID: 26250788). Microglia can be detected clearly using Catalog#27585-1-AP. The predicted MW of TMEM119 is 29 kDa. Catalog#27585-1-AP recognizes 45-50 kDa band may due to...
Microglia can be detected clearly using Catalog#27585-1-AP. The predicted MW of TMEM119 is 29 kDa. Catalog#27585-1-AP recognizes 45-50 kDa band may due to glycosylation.. 实验方案 Product Specific Protocols IF protocol for CL Plus 647 TMEM119 antibody CL647-27585 Download protocol FC ...
Cultured microglia treated with Lenti-Tmem119 or Tmem119 siRNA had decreased and increased expression of p-IRAK4 respectively than controls after OGD (p=0.0090 and p=0.0152 respectively, n=3-4). Pro-inflammatory cytokine (TNF-伪, IL-1尾, IL-6) levels were significantly lower in the plasma...
1. Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Meyer-Luehmann M, Knobeloch KP, Prinz M. Novel Hexb-based tools for studying microglia in the CNS. Nat Im...
(1, 2). TMEM119 is also expressed in a cell line of microglia, and TMEM119 immunoreactivity is observed in a specific subset of microglia in brains of neurodegenerative diseases, such as Alzheimer's disease (3). Mature human TMEM119 consists of a 71 amino acid (aa) extracellular domain (...
SMAD5 and RUNX2. Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages. Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons. ...
TMEM119, also known as Osteoblast Induction Factor (OBIF), plays important role in bone formation and normal bone mineralization. It is a highly expressed microglia-specific marker in both mouse and human. TMEM119 implicated in various cancers including gastric, osteosarcoma and hepatocellular carcinom...