MSI-H and TMB-high patients harbored more mismatch repair genes, such as MSH2, homologous recombination-related genes, such as ATR and BRCA2, and other genes including BRAF, KMT2D, and SMARCA4. None of the 6 MSI-H patients who received chemotherapy achieved a c...
Immune checkpoint inhibitors have been approved in the USA for tumours exhibiting mismatch repair deficiency (dMMR), microsatellite instability (MSI), or high tumour mutational burden (TMB), with regulatory and reimbursement applications in multiple othe
百度试题 结果1 题目研究表明,以下符合胆囊癌免疫治疗的指标是( ) A. TMB-Low B. MSI-High C. CEA-Low D. AFP-High 相关知识点: 试题来源: 解析 B 反馈 收藏
MSI-H status was less common in NENs compared to non-NENs [0.9% (N=12) vs. 2.5% (N=614), P<0.001].Conclusions:In this real-world NEN cohort, the actionable molecular alterations of TMB-H (13%) and MSI-H (0.9%) were observed. Taken together, the data suggest that molecular ...
The primary objective of this retrospective study was real-world applicability and use of immunotherapy in TMB/MSI-high patients to lend credence to and refine this biomarker. Methods:Charts of patients with advanced solid tumors who had MSI/TMB status determined by next generation sequencing (NGS)...