MSI-H status was less common in NENs compared to non-NENs [0.9% (N=12) vs. 2.5% (N=614), P<0.001]. Conclusions: In this real-world NEN cohort, the actionable molecular alterations of TMB-H (13%) and MSI-H (0.9%)
百度试题 结果1 题目研究表明,以下符合胆囊癌免疫治疗的指标是( ) A. TMB-Low B. MSI-High C. CEA-Low D. AFP-High 相关知识点: 试题来源: 解析 B 反馈 收藏
Immune checkpoint inhibitors have been approved in the USA for tumours exhibiting mismatch repair deficiency (dMMR), microsatellite instability (MSI), or high tumour mutational burden (TMB), with regulatory and reimbursement applications in multiple othe
1051P Impact of TLS status on outcomes in patients with high TMB or MSI-high status treated with immune checkpoint inhibitorsdoi:10.1016/j.annonc.2024.08.1109A. ItalianoJ.C. TrentG. SledgeJ. XiuE.S. AntonarakisG. D'AmatoD. Hsieh
MSI-H and TMB-high patients harbored more mismatch repair genes, such as MSH2, homologous recombination-related genes, such as ATR and BRCA2, and other genes including BRAF, KMT2D, and SMARCA4. None of the 6 MSI-H patients who received chemotherapy achieved a cl...