研究发现,辐射作为一种外源性危险信号分子可以激活TLR4,激活的TLR4通过髓样分化因子(myeloid differentiation factor 88, MyD88)依赖途径进一步激活核因子κB(nuclear factor kappa-B,NF-κB)等转录因子,最终促进促炎因子白细胞介素-6(inter...
TLR4 主要通过两个信号通路对肿瘤细胞凋亡进行调节,其一为 TLR4 通过 MyD88 蛋白调节核转录因子 kappaB(NF-κB)产生,促进肿瘤细胞增殖;其二为 TLR4 通过 PI3K/Akt 信号通路来抑制肿瘤细胞凋亡。 现就近年来TLR4 与肿瘤细胞凋亡相关性的研究进行综述。 【关键词】 Toll 样受体 4(TLR4); 肿瘤; 凋亡; 进展中图...
关键词: 慢性阻塞性肺疾病急性加重期 热毒宁注射液 TLR4/NF-κB炎症信号通路 DOI:Clinical effect of Reduning injection in treatment of acute exacerbation of chronic obstructive pulmonary disease and its effect on the Toll-like receptor 4/nuclear factor-kappa B inflammatory signaling pathway ...
Y Tomita,B Cakir,CH Liu,... - 《Angiogenesis》 被引量: 0发表: 2020年 NF-kappa B2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer Castration-resistant prostate cancer (CRPC) remain Lou,Wei,Liu,... - 《Molec...
黄精多糖通过TLR4-MyD88-NF-κB通路抑制缺氧/复氧H9c2心肌细胞炎性因子释放 目的探讨黄精多糖(Polygonatum sibiricum polysaccharides,PSP)对缺氧/复氧(hypoxia-reoxygenation,H/R)诱导H9c2心肌细胞Toll样受体4(Toll-like receptor 4,TLR4)-髓... 雷升萍 - 《中国药理学通报》 被引量: 14发表: 2017年 ...
Sevoflurane treatment enhanced the phosphorylation of NF-kappa B, and up-regulated the expressions of TLR4 and MyD88 (P < 0.05), which demonstrated that sevoflurane inhibited proliferation and differentiation of neuronal cells by activating TLR4/MyD88/NF-kappa B signaling both in vitro and vivo. ...
Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-kappa B sig... Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-κB signa...
Chitooligosaccharides Attenuate Lipopolysaccharide-induced Inflammation and Apoptosis of Intestinal Epithelial Cells: Possible Involvement of TLR4/NF-kappa B Pathway... RLZ Yang - 《Indian Journal of Pharmaceutical Education & Research》 被引量: 0发表: 2016年 Chitooligosaccharides Attenuate Lipopolysaccharide...
Panax Notoginseng flower saponins (PNFS) inhibit LPS-stimulated NO overproduction and iNOS gene overexpression via the suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways in RAW264.7 macrophages 来自 Springer 喜欢 0 阅读量: 197 作者:...
CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-魏B ... Qunfei,Chen,Ya-Jie,... - 《Biochemical & Biophysical Research Communications》 被引量: 0发表: 2015年 [Role of autophagy in quercetin-in...