TLR4/MyD88/NF-κB signaling pathwayObjectives:Danzhi Jiangtang capsule (DJC) is widely used for preventing and treating diabetic cardiomyopathy (DCM). However, the underlying mechanisms of the anti-inflammatory and antiapoptotic activities are unclear. Methods:In the Results:In vivo, DJC effectively...
However, MCP reduced the increased expression of TLR4, MyD88 and the level of p-NF-κB-p65 induced by ISO in the MCP-treated groups on day 15 and day 22 (p < 0.01 or p < 0.05). These results illustrated that MCP prevented the activation of the TLR4/MyD88/NF-кB signaling pathway...
The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signalling pathway and activation of melatonin receptor. Journ...
Western blotting和免疫荧光检测结果表明,LPS刺激BV2小胶质细胞后,TLR4/MyD88/NF-κB信号通路被激活,TLR4和MyD88的蛋白表达明显升高,而EGC能显著降低TLR4和MyD88的表达水平,抑制LPS诱导的NF-κB的核转位,抑制TLR4/MyD88/NF-κB信号通路的激活。 综上所述,EGC能够通过抑制TLR4/MyD88/NF-κB信号通路,抑制NF-κB核...
Further immunoblot detection was performed to determine the possible activation of signals downstream of TLR4/MyD88 (Fig. 3). Finally, we observed increased phosphorylation of inhibitor of nuclear factor kappa-B kinase subunit (IKK)α + β, NF-kappa-B inhibitor (IκB)α, and NF-κB p65...
TLR4/MyD88/NF-κB Signaling Pathway and Ulcerative Colitis 在线阅读 下载PDF 引用 收藏 分享 摘要 溃疡性结肠炎(UC)是一种发病机制尚未完全明确的非特异性炎症性疾病,免疫反应异常是UC发病的主要原因。研究表明,Toll样受体4(TLR4)通过胞内白细胞介素-1受体(IL-1R)同源结构域,并利用IL-1R下游信号传递......
Inhibition of miR-155 Attenuates CD14 Monocyte-Mediated Inflammatory Response and Oxidative Stress in Psoriasis Through TLR4/MyD88/NF-κB Signaling Pathway Login|Register Search in: Advanced search Clinical, Cosmetic and Investigational DermatologyVolume 15, 2022 -Issue...
4H). Taken together, these results demonstrated that FMT treatment suppressed the activation of the TLR4/MyD88/NF-κB signaling pathway in the colon, preserved the integrity of the intestinal barrier, and ameliorated the progression of intestinal inflammation. FMT treatment reduces plasma levels of ...
We investigated the effect of YQPC on the expression of upstream molecules in the NF-κB signaling pathway. As shown in Figure 5, the expression of TLR3 mRNA, TLR4 mRNA, MyD88 mRNA, and TRIF mRNA increased significantly after LPS + Poly(I:C) stimulation (P < 0.01, P < 0.01, P < ...
METH-induced activation of glial cells is associated with the activation of the TLR4/MyD88/NFκB signaling pathway. Moreover, melatonin administration led to recovery of these METH-induced markers to control levels. Thus, we conclude that melatonin could potentially be used as a cognitive enhancer...