TLR2-MyD88-NF-kappa B pathwayTNF-alphaIL-6Proteinuria is an important risk factor for chronic kidney diseases (CKD). Several studies have suggested that proteinuria initiates tubulointerstitial inflammation, while the mechanisms have not been fully understood. In this study, we hypothesized whether ...
gallisepticum-derived LAMPs with TLR2 and clarified the role of MyD88 in activating the NF-κB signaling pathway in DF-1 cells. The results showed that M. gallisepticum LAMPs up-regulated IL-1β expression, induced p65 nuclear translocation and phosphorylation, and activated NF-κB signaling ...
通过涉及 MYD88 和 TRAF6 的信号通路,TLR2 激活导致 NF-kappa-B 激活、细胞因子分泌和炎症反应的启动。该受体在识别特定配体方面发挥着关键作用,例如支原体巨噬细胞激活脂肽-2kD (MALP-2) 和伯氏疏螺旋体外表面蛋白 A 脂蛋白 (OspA-L),通常与 TLR6 协同作用。TLR2 与其他受体(包括 CD14 和 CD36)进行...
The aim of the present study was to investigate effects of dietary yeast culture on immune response related to TLR2-MyD88-NF-kβ signaling pathway, antioxidant capability and disease resistance against Aeromonas hydrophila for Ussuri catfish (Pseudobagrus ussuriensis). A total of 240 Ussuri catfis...
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM...
(PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The ...
(PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The ...
ＴＬＲ２／_ＴＬＲ４-ＮＦ-κＢ_信号通路在痛风中的研究进展 ㊀㊀［摘要］㊀痛风是由于血尿酸浓度升高，尿酸钠晶体在关节㊁肌腱和周围组织中沉积，从而导致炎症性关节炎间歇性发作㊂Ｔｏｌｌ样受体是先天免疫系统中模式识别受体的一种㊂痛风性关节炎是由于过饱和的尿酸钠晶体在血液中析出，并与巨噬细胞...
(PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The ...
A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6 J. Immunol., 175 (2005), pp. 4641-4646 CrossrefView in ScopusGoogle Scholar Sing et al., 2002 A. Sing, D. Rost, N. Tvardovskaia, A. Roggenkamp, A. Wiedemann, C.J. Kirsch...