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As tigerinin-1R exhibits great potential as a therapeutic agent for diabetes, in this study, we carried out a series of modifications based on the structure of tigerinin-1R to explore its structure–activity relationships. For the in vitro activity experiments, the islet cell line INS-1, ...
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The authors would like to thank the Regulatory Council D.O. Tiger nut of Valencia (Valencia, Spain) for providing "horchata" by-products. Moreover, we are also grateful for the technical support from the "Central Service for Experimental Research (SCSIE)" at the Universitat de València for...