Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. This progressive disorder is mostly known by its signature symptoms of bradykinesia and rest tremor. The progression of PD is divided into five stages by the Hoehn and Yahr...
For example, some people may never reach stage 5 of Parkinson’s disease. In uncommon cases, a person’s symptoms may become severe but still be limited to just one side of the body. Medically, these stages are used as a loose guide, and in fact, they make up one of the sections in...
Psychiatric complaints are common in Parkinson's disease (PD), and have a significant influence in disease outcome and quality of life. Little attention has been paid to psychiatric symptoms at early stage disease. We aimed to screen a population of early stage PD patients for psychiatric symptoms...
Structures outside the basal ganglia may compensate for dopamine loss in the presymptomatic stages of Parkinson's disease Structures outside the basal ganglia may compensate for dopamine loss in the presymptomatic stages of Parkinson's disease. FASEB J. 15, 1092-1094... E Bezard,AR Crossman,CE...
series of small strokes in the brain, cause the vast majority of dementias in the elderly. Other possible causes of dementia-like symptoms include infections, drug interactions, metabolic or nutritional disorders, brain tumors, depression or another degenerative disorders, such as Parkinson's disease....
Inhibition of carnitine palmitoyl-transferase 1 is a potential target in a mouse model of Parkinson’s disease Article Open access 21 January 2023 Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson’s disease mice: a combination of transcriptomics and meta...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus sig
of several kinases and phosphatases, most notably mitogen-activated protein kinases (MAPKs) and protein phosphatase 2A (PP2A or PP2), and transition metal dyshomeostasis, which could all arguably play a role, either as primary or secondary drivers of disease activity [11,12,13,16,28,29,30]....
While many aspects of social context can be difficult or impossible to change, understanding the pathways linking such aspects to health outcomes at the early disease stages also allows us to identify areas for health interventions. The link between higher social deprivation and greater limitations in...
An important aspect of disease-associated plant-microbe interactions are the host responses induced at pre-symptomatic and symptomatic stages of disease development [6]. Identification of the host responses especially at the infection or pre-symptomatic stage can be critical towards understanding the init...