For example, some people may never reach stage 5 of Parkinson’s disease. In uncommon cases, a person’s symptoms may become severe but still be limited to just one side of the body. Medically, these stages are used as a loose guide, and in fact, they make up one of the sections in...
Yahr, Emily
Psychiatric complaints are common in Parkinson's disease (PD), and have a significant influence in disease outcome and quality of life. Little attention has been paid to psychiatric symptoms at early stage disease. We aimed to screen a population of early stage PD patients for psychiatric symptoms...
Structures outside the basal ganglia may compensate for dopamine loss in the presymptomatic stages of Parkinson's disease. FASEB J. 15, 1092-1094... E Bezard,AR Crossman,CE Gross,... - 《Faseb Journal》 被引量: 0发表: 2001年 Presymptomatic compensation in Parkinson's disease is not dopami...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus sig
Nonetheless, studies in animal models of other neurodegenerative diseases, e.g., multiple sclerosis20 and Parkinson’s-95 and Alzheimer’s disease96 have shown that HFD results in more severe disease progression, demyelination, inflammation, death of neurons and brain atrophy. HFD results in up...
This reveals a hominin forager capable if not of hunting (evidence for which remains indirect92) then at least of confrontational scavenging93. The same pattern of carcass access and utilization persists into later stages of the early Pleistocene94and, at some sites, even expands to include Size...
Central to these concepts is the digestion of food within the gut. In all intestines, peristaltic action of the gut moves food through the various stages of digestion from the anterior end towards the posterior, with the rate of flow dependent on signals, both intrinsic and extrinsic to the ...
Furthermore, there is evidence linking risk of osteoarthritis to lower educational attainment. However, the inter-play of these factors with key social factors (e.g., social deprivation) at the early stages of osteoarthritis are not understood. Here, we used data from waves 4, 5, 6 and 7 ...
activators of HDAC1 yielded exifone as an HDAC activator and a strong candidate for such a therapeutic strategy (Supplementary Fig.9a)52. Exifone has also been shown to have pro-cognitive effects in animal models and in patients with Alzheimer’s-type dementia and Parkinson’s disease53,54,55...