Well, “The Silencing” does indeed put something new on the table, a killer dressed in a costume that looks like an overgrown Muppet, or maybe that Easter mascot from “Toni Erdmann.” It’s big and it’s furry and it must be hard to get around in, or I guess it would be hard ...
et al. Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis. Cancer Cell 37, 55–70.e15 (2020). CAS PubMed PubMed Central Google Scholar Jakobsen, T. et al. Genome-wide circular RNA expression patterns reflect resistance to immunomodulatory drugs in multiple...
Nature Reviews Drug Discovery volume 21, pages 655–675 (2022)Cite this article 70k Accesses 114 Altmetric Metrics details Abstract Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable...
Of course, it's never going to compete with high-end brands, like Bose, but we think most people will be happy with the level of silencing on offer here. In our review, we wrote: "It’s certainly enough to keep conversations muted and loud noises dulled when you’re out in public....
take with the Pixel 8a, as long as they're uploaded to Google Photos. With Google Photos, you get access to the amazing Magic Editor, which lets you change backgrounds or move objects around. Plus, there's the Magic Audio Eraser in the video recorder for silencing annoying background ...
RNA interference (RNAi) is an ancient and evolutionarily conserved gene-silencing mechanism that is triggered by double-stranded (ds)RNA. dsRNA, which is produced endogenously or introduced exogenously, is processed into small (∼21–23-nucleotide (nt)) duplexes, and the antisense strands are lo...
of retrotransposons may also result in cytotoxic polypeptides (Li et al.2015). In healthy cells most of them are thought to be silenced, but a loss of their silencing has been associated with age-related degenerative disorders, most notably Alzheimer’s disease and ALS (Jönsson et al.2020)...
[36,37,38]. Silencing the transferrin receptor (TFRC) gene, which encodes TFR1, has been shown to inhibit erastin-induced iron depletion [39]. Both TF and TFRC play essential roles in the regulation of ferroptosis by promoting the cellular uptake of iron from the extracellular milieu. ...
et al. Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 129, 473–484 (2007). CAS PubMed Google Scholar Mouchiroud, L. et al. The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and ...
A. et al. CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs. Cell Stem Cell 18, 541–553 (2016). CAS PubMed PubMed Central Google Scholar Balboa, D. et al. Conditionally stabilized dCas9 activator for controlling gene expression in human cell ...