Integrated mining of public transcriptomic and ChIP-Seq datasets has the potential to illuminate facets of mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP), which incorporates stable community ...
1c), suggesting there is a H2Bub-independent signaling pathway for glucose to induce H3K4me3. We also examined the effect of glucose on the activity of Set1-containing complex (COMPASS). COMPASS (Spp1-CBP) was purified from cells grown in 0.05% glucose and 2% glucose, respectively and the...
Consumption of over-the-counter probiotics for promotion of health and well-being has increased worldwide in recent years. However, although probiotic use has been greatly popularized among the general public, there are conflicting clinical results for m
The cardioprotective effect of paeoniflorin is associated with the inhibition of MAPK signaling pathways. In additon, we only investigated the effect of paeoniflorin on signaling pathways but lack of the influence on blood vessels, which considered a main constraint leading to cardiac remodeling. We ...
To verify the signaling pathways possibly involved in the contribution of the piezoelectric hydrogels to M2 polarization, an inhibitor (BEZ235, 0–200 nmol/L, Selleck, USA) of PI3K was added in complete cell culture medium to culture RAW 264.7 cells on piezoelectric hydrogels. LPS (200 ng/ml...
(VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway or other signaling pathway. Additionally, exosomes are potential therapeutic vectors that can deliver many types of cargoes to different cells. In this review, we summarize the roles of exosomes ...
by the Deutsche Forschungsgemeinschaft (German Research Foundation) (SPP 1665, PO1799/1-2, PO1799/2-1, PO1799/3-1 and PO1799/6-1 to A.P.; Project ID 431549029-SFB 1451 to T.K.; 233886668-GRK1960 to C.C. and M.-A.C.; and EXC2030 CECAD, to T.K.) by the Interdisciplinary...
This work was supported by an ERC Consolidator grant (GA 615585) MYCOTHIOLOME and grants from the Deutsche Forschungsgemeinschaft (AN746/4-1 and AN746/4-2) within the SPP1710, by the SFB973 project C08 and by the SFB/TR84 project B06 to H.A. We further acknowledge funding from the ...
9i). Together, these results suggest that social contact and new object exploration are regulated by the mPFC–LH pathway, while food intake can be terminated by mPFC signals to the LH and by further pathways. Fig. 6: Beta-rhythmic mPFC–hypothalamic signaling promotes behavioral transitions. a...
Subpopulations of tumor cells exhibited signatures of proliferation, KRAS signaling, cell stress and epithelial-to-mesenchymal transition. Mapping mutations and copy number events distinguished tumor populations from normal and transitional cells, including acinar-to-ductal metaplasia and pancreatic ...