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The tumor cell has a very distinctive metabolism. It acts as a metabolic trap for host nutrients thus taking vital compounds for the metabolism of the host. Depending on the particular tumor growing pattern, cancer cells use preferentially glucose or amino acids for their energetic or biosynthetic ...
Our findings reveal the potential mechanism by which tumor cells promote brain metastasis by altering their metabolism to mimic the CNS microenvironment. We identified high levels of GABA and its role in enhancing brain metastasis in NSCLC, elucidating the underlying mechanism involving the FOXA2/ABAT...
Small cell carcinoma is primarily a pulmonary neoplasm that rarely arises in extrapulmonic sites including salivary glands of the head and neck. Twelve cas... GNEPP,D. R. - 《Cancer》 被引量: 138发表: 2015年 Mesenchyme specificity in rodent salivary gland development: the response of salivary...
This observation presented a paradox that still has not been completely resolved: Why do proliferating cells, which ostensibly have a great need for ATP, use such a wasteful form of metabolism? Warburg proposed that tumor cells harbor a permanent impairment of oxidative metabolism resulting in a ...
(UA) is a secondary metabolite derived from the gut microbiome metabolism of ellagitannins and ellagic acid, which are abundant in pomegranates, strawberries, and various nuts [126,127]. UA, a phenolic compound, significantly reduced histological alterations, the wet-to-dry lung weight ratio, and...
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