Biofilms are “syntrophic consortia of microorganisms in which cells stick to each other and often also to a surface” [34,35]. These adherent cells become embedded within a slimy extracellular matrix that is composed of extracellular polymeric substances (EPSs) [35]. The cells within the ...
The year 2023 marks the mid-point of the 15-year period envisaged to achieve the Sustainable Development Goals, targets for global development adopted in September 2015 by all United Nations Member States. To help track where we are on this journey, and to amplify success stories, in this ...
Rule of five A set of criteria, known collectively as Lipinski's 'rule of five', that identify several key properties that should be considered for compounds with oral delivery in mind. These properties are as follows: molecular mass < 500 Da, cLogP < 5, number of hydrogen-bond donors <...
Space probes can be routed to fly through these plumes performingin situinvestigations of the plume material, which is ejected from the interior oceans. However, to be able to interpret the data collected by instruments on board of missions, such as NASA’s Cassini or ESA’s JUICE (JUpiter I...
However, the presence of QQ enzymatic activity was 1.63-fold higher in the 2000 m sample. The analysis of putative QQ enzymes in the metagenomes supports the relevance of QQ processes in the deepest samples, found in cultivable bacteria. Despite the unavoidable biases in the cultivation methods...
A decline in the discovery of new antibacterial drugs, coupled with a persistent rise in the occurrence of drug-resistant bacteria, has highlighted antibiotics as a diminishing resource. The future development of new drugs with novel antibacterial activi
We further investigated the metabolic interactions among these co-occurring microorganisms of E. bugandensis. For this, we constructed 47 genome-scale metabolic models and simulated them on the described media (details in the “Methods” section). To evaluate the effect of the surrounding bacteria ...
Here, we performed the first matched time series characterization of the NICU and infant gut. Our analysis used metagenomic sequencing of microbial community DNA extracted from fecal samples to evaluate the metabolic potential of gut colonizing microorganisms and a recently developed ‘expectation ...
Based on end-sequences of fosmid clones from 1 flying squirrel, we inferred that microbial metabolism greatly contributed to intestinal functions, including degradation of carbohydrates, metabolism of proteins, and synthesis of vitamins. Moreover, 33 polysaccharide-degrading enzymes and 2 large genomic ...
Also, the number and position of substituents in the benzene ring of phenolic acids influence the antibacterial potential of these acids against different microorganisms [91]. In general, the presence of a double bond in the α and β positions of the side chain and a methyl group in the γ...