but in turn target RNAs are negative regulators of miRNA function. This is because they compete for binding to common miRNAs, i.e., they act as competing endogenous RNAs (ceRNAs). ceRNA partners that share MRE(s
The structural redundancy found in many small molecules suggests that they possess a similar capacity for generalized building block-based construction. It is also encouraging that many customized iterative synthesis methods have been developed that already improve access to specific classes of small ...
inorganic–protein frameworkspeptidesself-assemblyterpyridinesHerein we describe the design and synthesis of the first series of di-functional ligands for the directed construction of inorganic-protein frameworks. The synthesized ligands are composed of a metal-ion binding moiety (terpyridine-based) ...
Cytochromes are the protein structures consisting of heme factor that acts as the electron transfer agents in the WLP (Figure 1A). Once the electrons are received by the anode, they are transferred to the cathode via an external circuit using either a natural voltage gradient developed between ...
IF and keratin protein expression depends on the cell/tissue type (Fig. 1A) and the differentiation level (Kim and Coulombe, 2007; Strnad et al., 2008). These proteins are the building blocks of mechanically strong structural filaments, which also possess many other dynamic functions (Magin ...
For example, ScyD, ScyE, and ScyF, none of which had been assigned a protein function by annotation, each contain a signal peptide export domain in their derived protein sequence. These N-terminal signature sequences are often associated with periplasmic proteins, suggesting that some stages of...
There are over 20,000 different proteins in the body (1). How do proteins have so much functional diversity based upon only 20 building blocks? The answer lies in the complexity of primary, secondary, tertiary, and quaternary structure (Figure 1). Figure 1. The four levels of protein ...
Interestingly, dramatically increased protein levels (by approximately tenfold) were observed in the bud21∆ + pLJ529-ZNF1 strain for most Hxts, including Hxt2 and Hxt7, which are required for xylose uptake (Table 2). Improved tolerance to lignocellulosic inhibitors in the engineered bud...
design of small-molecule binders6; as protein targets are so much bigger and because nonpolar interactions are the primary driving force for protein–protein interactions, we focused the RIF generation process on nonpolar sites in specific surface regions of interest. For example, for the design of...
building blocks (amino acids, nucleotides, glucose, etc.) to the parasite. Among the many strategies put in place to allow optimal development in the host cell, a singular example is provided byPlasmodium, which is characterized by the presence of tRip (tRNA import protein), a unique tRNA ...