Trends in Cell Biology . 1994Massague, J., Attisano, L. and Wrana, J. L. (1994). The TGF-β family and its composite receptors. Trends Cell Biol. 4, 172-178.Massague, J., L. Attisano & J.L. Wrana: The TGF-beta family and its composite receptors. Trends. Cell. Biol. 4, ...
AJL Wrana - 《Trends in Cell Biology》 被引量: 508发表: 1994年 The TGF-β family and its composite receptors of animal growth and development, biologists have often come upon members of the transforming growth factor beta (TGF-beta) family and have realized that these are among the most ...
The objective of the current study was to determine the role of transforming growth factor beta (TGFbeta) during seminiferous cord formation and embryonic ... AS Cupp,G Kim,MK Skinner - 《Biology of Reproduction》 被引量: 171发表: 1999年 Expression of the TGF-|[beta]| Family of Ligands ...
In order to develop effective novel therapeutic targets, it is important to understand parasite biology and immune evasion mechanisms. Genes previously identified as encoding for homologues of the TGF-β family are present in a number of parasitic worms and these molecules may offer novel therapeutic...
2011, International Journal of Radiation Oncology Biology Physics Citation Excerpt : It regulates cell proliferation and is important for endothelial cell survival and vessel repair. Mutations in endoglin have been linked to the vascular disease hereditary hemorrhagic telangiectasia, characterized by dilated ...
cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. Th...
Transforming growth factor-beta-1 (TGF-β1) is known to regulate various ovarian functions. However, whether VEGF can be regulated by TGF-β1 in human granulosa cells has not been determined. In addition, the role of TGF-β1 in the pathogenesis of OHSS remains unknown. In the present ...
Transforming growth factor β proteins (Tgfβs) are secreted cytokines with well-defined functions in the differentiation of the musculoskeletal system of the developing limb. Here we have studied in chicken embryos, whether these cytokines are implicate
Subretinal fibrosis remains a major obstacle to the management of neovascular age-related macular degeneration. Choroidal pericytes were found to be a significant source of subretinal fibrosis, but the underlying mechanisms of pericyte-myofibroblast tran
In normal cells, the optimal activation of T cells occurs through the upregulation of CD40 and B7-1/2 on dendritic cells [13], but these signals are strongly inhibited by the TME. The TME produces a unique immunosuppressive environment with neoantigens, cytokines (e.g., TGFβ) and immune...