TGF-beta 1/Tregimmune imbalanceINFLAMMATIONTGF-BETA-1STENTRISKObjective: This research aimed to investigate the level of TGF-beta 1/Treg pathway related factors in patients with coronary heart disease (CHD) after PCI, so as to evaluate the prognostic value. Methods: This is prospective research....
纤维化疾病模型构建与干预在肝纤维化、肺纤维化等疾病中，TGF-beta 1通过激活成纤维细胞和胶原沉积驱动病理进程。重组蛋白用于构建体外和动物模型（如CCl4诱导的肝纤维化），评估抗纤维化药物的疗效。免疫调节与炎症反应研究TGF-beta 1在调节Th17/Treg细胞平衡中起关键作用，其重组蛋白被用于诱导Th17细胞分化，探索自身...
最重要的是,tgfβ诱导调节性t细胞(treg)分化。treg通过产生免疫抑制细胞因子(il-10、tgfβ和il-35)、表达抑制分子(ctla-4)以及通过cd39将atp水解为腺苷,进一步抑制炎症。 4.鉴于cd39和tgfβ在调节肿瘤免疫应答中的作用,仍然需要对抗cd39活性的治疗剂或对抗cd39和tgfβ活性的治疗剂来治疗疾病,例如癌症。 技术实现...
其重要性延伸至调节激活的调节性 T 细胞 (Treg) 表面的 TGF-β-1 (TGFB1) 激活。此外,LRRC32 的参与对于上腭发育过程中的上皮融合至关重要,它调节 TGF-β-3 (TGFB3) 的激活。LRRC32 与 LAP 的结合可直接与 TGFB1、TGFB2 和 TGFB3 相互作用,调节 TGF-β-1 和 TGF-β-3 的激活,突显其在微调 ...
GARP/latent TGF-b1 复合体蛋白是在外源 IL-6 存在时是 Th17 分化的有效诱导因子,在 IL-2 存在时是 Treg 的诱导因子。GARP&Latent TGF beta Complex Protein, Mouse (Biotinylated, HEK293, His-Avi) 是由 HEK293 细胞表达的 (GARP (I18-N628)&TGF-b1 (L30-S390)) 重组蛋白,带有 His 标签. Synonyms...
humanNeutralization,IHC Am J Pathol Latent-transforming growth factor β-binding protein 1/Transforming growth factor β1 complex drives antitumoral effects upon ERK5 targeting in melanoma Sci Rep Treg-derived TGF-β1 dampens cGAS-STING signaling to downregulate the expression of class I MHC complex...
Moreover, TGF-β1 has been shown to act as a costimulatory factor for expression of Foxp3, leading to the differentiation of CD4+CD25+ Treg cells from peripheral CD4+CD25- progeny. TGF-β-induced regulatory T cells have been termed Ti-Treg. 产品留言 标题 联系人 联系电话 内容 ...
TGF-beta 1 (Transforming Growth Factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure (1‑7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switche...
摘要: Foxp3(+) regulatory T cells (Treg) playing a cruci 年份: 2016 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 ResearchGate (全网免费下载) or.nsfc.gov.cn (全网免费下载) jimmunol.org (全网免费下载) 相似文献 参考文献Mechanisms of Allergen-Specific Immunotherapy and Novel Ways ...