TGF-beta 1/Tregimmune imbalanceINFLAMMATIONTGF-BETA-1STENTRISKObjective: This research aimed to investigate the level of TGF-beta 1/Treg pathway related factors in patients with coronary heart disease (CHD) after PCI, so as to evaluate the prognostic value. Methods: This is prospective research....
纤维化疾病模型构建与干预在肝纤维化、肺纤维化等疾病中，TGF-beta 1通过激活成纤维细胞和胶原沉积驱动病理进程。重组蛋白用于构建体外和动物模型（如CCl4诱导的肝纤维化），评估抗纤维化药物的疗效。免疫调节与炎症反应研究TGF-beta 1在调节Th17/Treg细胞平衡中起关键作用，其重组蛋白被用于诱导Th17细胞分化，探索自身...
GARP(LRRC32)是一种跨膜蛋白,结合潜在的TGF-β1并将其固定在Treg表面。并已被证明可以促进转化生长因子β(TGF-β)的活化和分泌。GARP在表面活化的Tregs上高度表达,并增强Tregs的抑制功能。此外,GARP可以与潜在的转化生长因子β(TGF-β)结合,从而促进TGF-β的分泌和激活。TGF-β对Tregs的稳态和功能起着关键作用...
TGF-β regulates the activation, proliferation, and apoptosis of B cells. However, this effect of TGF-β on the B-cell-mediated antitumor immune response has not been well studied [86,87].
45.图31a显示了向同种异体dc诱导的自体t细胞中添加treg可抑制t细胞的ifn-γ分泌。图31b至31d显示了示例性抗cd39/tgfβ陷阱分子对treg介导的人类t细胞抑制的影响,通过cd4 + t细胞增殖%(图31b)、cd8 + t细胞增殖%(图31c)和ifn-γ分泌改变(图31d)测定。
其重要性延伸至调节激活的调节性 T 细胞 (Treg) 表面的 TGF-β-1 (TGFB1) 激活。此外,LRRC32 的参与对于上腭发育过程中的上皮融合至关重要,它调节 TGF-β-3 (TGFB3) 的激活。LRRC32 与 LAP 的结合可直接与 TGFB1、TGFB2 和 TGFB3 相互作用,调节 TGF-β-1 和 TGF-β-3 的激活,突显其在微调 ...
TGF-beta 1 (Transforming Growth Factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure (1‑7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switche...
PE anti-mouse LAP (TGF-β1) Antibody - Transforming growth factor beta (TGF-β) is a cytokine that has critical functions in immune response by regulating Treg and Th17 cells.
TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TG...
Given the role of Treg-derived TGF-β in suppressing the immune response in the tumour microenvironment, there has been interest in targeting this pathway as an alternative approach to cancer immunotherapy. For example, therapeutic agents capable of dampening this pathway may serve as useful tools ...