Transforming growth factor beta (TGF-β) is a potent pleiotropic polypeptide cytokine, with a complex and context dependent control of its activation, signaling and effector functions. This cytokine is pivotal in the regulation of immunological responses, tumor initiation and development, stromal homeosta...
Autocrine and paracrine effects of TGF-β during normal thymopoiesis; Role for TGF-beta1 in the generation of dendritic cells; Activation of macrophage function by TGF-β.LetterioLaboratoryJohnLaboratoryJ.LaboratoryRobertsLaboratoryAnitaLaboratory
TGF beta pathway activation and the SMAD signaling pathway Before binding to its receptors, TGF beta is activated from a large latent complex comprised of LTBP and LAP (Latency Associated Peptide). Ligand binding to the Type II receptor (TGF betaRII...
TGF-beta plays an important role in the regulation of T helper (TH) cell differentiation. The presence or absence of TGF-beta in combination with other cytokines (IL-6, IL-1, or IL-23) is critical for the developmental program of regulatory and effector T helper cells and for the final ...
Cytokine polymorphisms have previously been linked with their differential production and expression in mal- aria [5,6], with variation in promoter sequences thought to alter specific transcription factor recognition sites, transcriptional activation and cytokine production [5]. However, the association ...
Cytokine polymorphisms have previously been linked with their differential production and expression in malaria [5, 6], with variation in promoter sequences thought to alter specific transcription factor recognition sites, transcriptional activation and cytokine production [5]. However, the association betwe...
Thus, Nrp1 might collaborate with other latent TGF-β receptors in TGF-β capture and activation. We also show that Nrp2 has activities similar to Nrp1. We conclude that Nrp1 is a co-receptor for TGF-β1 and augments responses to latent and active TGF-β. Since TGF-β promotes ...
(TβR) in the TGF-β pathway activation, our aim was to investigate the effects of CCN2 in the regulation of TβRI and TβRII levels in vascular smooth muscle cells (VSMCs). While no differences were observed in TβRI levels, an increase in TβRII expression at both gene and ...
ARTICLES nature publishing group Lactoferrin causes IgA and IgG2b isotype switching through betaglycan binding and activation of canonical TGF-b signaling Y-S Jang1, G-Y Seo1, J-M Lee1, H-Y Seo1, H-J Han1, S-J Kim1, B-R Jin1, H-J Kim1, S-R Park2, K-J Rhee3, W-S Kim...
Taylor AW.Review of the activation of TGF-β in immunity. Journal of Leukocyte Biology . 2008Taylor A.W. 2008. Review of the activation of TGF-β in immunity. J. Leukocyte Biol. 85: 1-5.Review of the activation of TGF-beta in immunity. Taylor Andrew W. Journal of Leukocyte Biology ...