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转化生长因子 (Transforming growth factor beta,TGF-β) 是一类多功能的细胞因子,可由多种组织细胞产生。TGF-β 信号通路是由众多成员的多功能细胞因子,与相应的受体、细胞内信号转导分子组成的通路,能影响疾病发生和发展,调节基因的转录,控制着细胞周期,影响细胞的增殖、分化、黏附、转移和凋亡。值得注意的是,TGF-...
10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139.11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230.12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer...
2. Moustakas A, Pardali K, Gaal A, HeldinCH. Mechanisms of TGF-beta signaling in regulation of cell growth anddifferentiation. Immunol Lett. 2002 Jun 3; 82(1-2): 85-91. PubMed ID: 12008039 3. Roberts AB, Derynck R. Meetingreport: signaling sc...
Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. 11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230. 12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J...
2. Moustakas A, Pardali K, Gaal A, HeldinCH. Mechanisms of TGF-beta signaling in regulation of cell growth anddifferentiation. Immunol Lett. 2002 Jun 3; 82(1-2): 85-91. PubMed ID: 12008039 3. Roberts AB, Derynck R. Meetingreport: signaling schemes for TGF-beta. Sci STKE. 2001 De...
10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. 11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230. 12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal ca...
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9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19...