Renal fibrosisPulmonary fibrosisCardiac fibrosisCancerTransforming growth factor-beta 1 (TGF-beta 1) is considered as a crucial mediator in tissue fibrosis and causes tissue scarring largely by activating its downstream small mother against decapentaplegic (Smad) signaling. Different TGF-beta signalings ...
Key words:TGF beta1 / Smad;signaling pathway;renal interstitial fibrosis;traditional Chinese medicine single drug;compound tradi tional Chinese medicine 肾间质纤维化(renal interstitial fibrosis,RIF)是各种慢性 进行性肾脏疾病渐进发展到终末期肾功能衰竭的共同形态 学特点和必然结局 [1] 。近年来中医药防治...
Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-??/Smad signaling pathway. Chem-Biol Interact. 2014; 224 :58–67. ... MH Feng,JW Li,HT Sun,... - 《Human Cell》 被引量: 0发表: 2019年 Sauchinone Protects Renal Mesangial Cell Dysfunction against Angiot...
Collectively, these results indicate that Nrf2 might be an effective inhibitor of Smad-dependent Tgf-beta1 signaling, and imply the anti-fibrotic role of Nrf2 in renal diseases. 展开 关键词: Renal fibrosis Nrf2 Smad7 DOI: 10.1254/jpssuppl.WCP2018.0_PO1-3-20 ...
pressure (IOP) at the GFS surgical site and diminished subconjunctival cellular infiltration and scarring. Additionally, in mice treated with tacrolimus (TAC) and FK12EC KO mice, SB505124 inhibited the activation of endothelial TGF-β receptors and the induction of hyalinosis in renal arterioles....
Diabetic nephropathy (DN) is characterized by renal fibrosis and inflammation. Increasing evidence shows that TGF-beta/Smad signaling plays a critical role in DN. This thesis tested a hypothesis that TGF-beta/Smad signaling may play a central role in diabetic kidney injury and targeting this ...
Cheng X,Gao W,Dang Y,et al.Both ERK/MAPK and TGF-beta/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation[J].J Diabetes Res,2013,2013:463740.Cheng X, Gao W, Dang Y, Liu X, Li Y, Peng X, Ye X (2013) Both ERK/...
Here we studied the roles of Smad4 to regulate TGF-[beta] signaling in a mouse model of unilateral ureteral obstruction using conditional Smad4 knockout mice and in isolated Smad4 mutant macrophages and fibroblasts. Disruption of Smad4 significantly enhanced renal inflammation as evidenced ...
Jiang, Kang,Ma,etc.Emodin ameliorates renal fibrosis in rats via TGF-beta 1/Smad signaling pathway and function study of Smurf 2[J].2018,50(2).Ma L, Li H, Zhang S, et al. Emodin ameliorates renal fibrosis in rats via TGF ⁃ β1/Smad signaling pathway and function study of Smurf ...
Cheng X, Gao W, Dang Y, Liu X, Li Y, Peng X and Ye X: Both ERK/MAPK and TGF‑Beta/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation. J Diabetes Res 2013: 463740, 2013....