TGF-beta/SmadMMP-2/TIMP-1Ethnopharmacological relevance: Curcuma wenyujin Y.H. (CW), a variety of Curumae Rhizoma, which documented in China Pharmacopeia, has long been used as plant medicine for its traditional effect on promoting Qi, activating blood stagnation and expelling blood stasis. ...
Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity. AntibacterialAntibioticMMPParasiteribosome $45 In Stock Size QTY Cited ...
Doxycycline (Doxiciclina) 属于四环素类抗生素,是一种广谱的金属蛋白酶 (MMP) 抑制剂,具有口服活性。Doxycycline 具有抗菌活性和抗肿瘤活性。 AntibacterialAntibioticMMPParasiteribosome ¥ 398 现货 规格 数量 客户已引用 "Halofuginone"的相关化合物库 抗感染天然产物库 ...
S-K Leivonen, R Ala-aho, K Koli, R Grénman, J Peltonen, V-M Kähäri, Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells, Oncogene, 2006, 25, 18, 2588 CrossRef 12 Shigeki Tsukada, Christopher J. Parso...
Skullcapflavone II 是从黄芩中提取的黄酮,具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。
LNT-229 and LN-308 cell lines. Pirfenidone (< 5 mM) reduces TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (< 8.3 mM) inhibits the activity of recombinant furin and downregulates the expression of MMP-11 in a dose-depen...
The expression of MMP1 was reduced markedly while TIMP1 synthesis was enhanced after BGF treatment. ERK phosphorylation exhibits a significant increase in the mice treated with BGF. Furthermore, BGF can markedly upregulate TGF-β1 expression. The p-smad2 showed 2-fold increases compared with the ...
We found that in pancreatic cancer cells Smad proteins and Sp1 cooperatively regulate expression of a distinct set of TGFbeta target genes potentially involved in tumor progression, including MMP-11, cyclin D1 and Smad7. Mechanistically, TGFbeta rapidly induces nuclear translocation of Smad proteins ...
Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1. Chronic liver injury leads to a progressive wound healing response that eventually results in hepatic fibrosis characterised by net deposition of fibrillar... T Takahra...
MMP-1 and MMP-3 protein levels in UVB-irradiated HaCaT cells exhibited an increase of 83.74% and 60.96%, respectively, as shown in Figure 6. Upon JAUN treatment, there was a decrease in MMP-1 and MMP-3 production, surpassing the reductions observed in the ascorbic acid group. Particularly...