M. Modulation of the TGF β /Smad signaling pathway in mesangial cells by CTGF/CCN2. Experimental Cell Research . 2005; 307 (2):305–314. doi: 10.1016/j.yexcr.2005.03.022. [ Cross Ref ]Wahab NA, Weston BS, Mason RM (2005) Modulation of the TGFbeta/Smad signaling pathway in ...
气活血方大剂量组、中剂量组 TGF β、Smad2、CTGFmRNA 和 蛋白表达明显下降,而Smad7 表达明显升高。提示益气活血 方可以下调 TGF β、Smad2 和上调 Smad7 的表达来抑制 CT GF 的表达,进而遏制肾纤维化的进程。 3 思考与展望 TGF β1 / Smad 信号传导通路是肾间质纤维化发生发展 重要的通路,抑制TGF β1...
Rishi Kundi and Evan Ryer and Kamiya Kentaro and Bo Liu and K. Craig KentJournal of the American College of SurgeonsKundi R, Ryer E, Kentaro K, Liu B, Kent KC. TGF-/Smad3-induced production of CTGF by medial smooth muscle cells mediates remodeling behavior in adventitial fibroblasts...
Decorin alleviated chronic hydrocephalus via inhibiting TGF-beta1/Smad/CTGF pathway after subarachnoid hemorrhage in rats. Brain Res. 2016;1630:241–53.Yan H, Chen Y, Li L, Jiang J, Wu G, Zuo Y, Zhang JH, Feng H, Yan X and Liu F: Decorin alleviated chronic ...
In addition, Smad phosphorylation and subsequent CTGF and TIMP-1 expression were markedly reduced in the presence of neutralizing monoclonal TGF beta(1-3) antibody. Furthermore, CsA administration significantly increased the serum levels of the liver enzymes alanine aminotransferase (ALT) and aspartate ...
With resveratrol intervention, the protein and RNA expressions of TGF-beta 1, a-SMA, Smad3/4, p-Smad3/4, CTGF, and p-ERK1/2 were markedly downregulated. Similarly, the protein and RNA expression levels of Col-1 and Col-3 were significantly downregulated. However, Smad7 and ERK1/2 ...
TGFβ1, but not BMP4, induced PAI1 and CTGF expression. BMP4 did not alter TGFβ1-mediated transcriptional responses. In contrast, TGFβ1 attenuated BMP4-mediated ID1/2 induction and the BRE-luc response in donor HPASMCs. Moreover, TGFβ1 abolished BMP4 responses in PAH PASMCs with ...
Moreover, ADF significantly attenuated the TGF-尾1/Smad2 pathway activation by decreasing serum TGF-尾1 (ADF vs control (p=0.011); HF vs HF+ADF (p=0.008)), Smad2 (ADF vs control (p=0.001); HF vs HF+ADF (p=0.001)), and CTGF (ADF vs control (p=0.018); HF vs H...
After 21 days, the rats were sacrificed, and serum samples were analyzed using the ELISA method to measure transforming growth faktr-Beta (TGF-尾1), mother against decapentaplegic homolog 2 (Smad2), and connective tissue growth factor (CTGF) levels. Additionally, knee joint s...
NLD attenuated TGF-beta 1-induced expression of fibrotic markers including type I and III collagen, fibronectin, alpha-SMA, and CTGF in human pulmonary fibroblasts (WI-38 VA-13 and HLF-1 cells). Mechanism study indicated that NLD suppressed TGF-beta 1-induced up-regulation of T beta R I,...