Circulating polyomavirus middle T antigen-expressing tumor cells did not grow ex vivo in the presence of the TGF-beta antibody, suggesting autocrine TGF-beta is a survival signal in these cells. Radiation failed to enhance lung metastases in mice bearing tumors that lack the type II TGF-beta ...
Neutralizing TGF-beta1 antibody infusion in neonatal rat delays in vivo glomerular capillary formation 1. Kidney Int 1999; 56:1334-48.Liu A, Dardik A, and Ballermann BJ. Neutralizing TGF-beta1 antibody infusion in neonatal rat delays in vivo glomerular capillary formation 1. Kidney Int 56: ...
The invention relates to an antibody, or an antigen-binding fragment thereof that neutralizes human TGF-1 and has Kless than 40 pM. The invention further relates to a composition comprising said antibody and to use of the antibody claimed for the preparation of medicinal agent for the treatment...
Neutralizing TGF-β1 antibody infusion in neonatal rat delays in vivo glomerular capillary formation 1. Kidney Int 56: 1334-1348, 1999.Liu et al., " Neutralizing TGF-beta1 antibody infusion in neonatal rat delays in vivo glomerular capillary formation, " Kidney Int, 56:1334-1348 (1999)....
A Potent Pan-TGF beta Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus MonkeysTGF betacardiovascular toxicityvalvulopathymousecynomolgus monkeysTransforming growth factor beta (TGF(beta) signaling has been recently shown to reduce antitumor response to PD-L1 blockade, ...
(1993). Experimental allergic encephalomyelitis: neutralizing antibody to TGF beta 1 enhances the clinical severity of the disease. J. Neuroimmunol. 47, 1-7. doi: 10.1016/0165-5728(93)90278-7Johns LD, Sriram S. Experimental allergic encephalomyelitis: neutralizing antibody to TGF beta 1 enhances ...
S2249IL-15 Neutralizing Antibody Inhibits Cytotoxic T Cell-Mediated Tissue Damages and Increases TGF-Beta Expression in Celiac Diseasedoi:10.14309/01.ajg.0001038364.16389.c3Gaetano IaquintoRita Hospital, Atripalda, Campania, Italy;Vera RotondiAufiero...
single-domain antibodyVHHTGF-betanext-generation DNA sequencingphage displayThe epitope specificity of therapeutic antibodies is often critical to their efficacy and mode of action. Here, we report the isolation of single-domain antibodies (sdAbs) against a pre-specified epitope of TGF-beta 3: ...
Rescue of premature coronal suture fusion with TGF-beta2 neutralizing antibody in rabbits with delayed onset synostosis - Journal of Oral and Maxillofacial Surgerydoi:10.1016/j.joms.2004.05.197Michael W. MorrisonJ. ShandR. MitchellA.M. Moursi...
Rescue of Premature Coronal Suture Fusion With TGF-beta 2 Neutralizing Antibody in Rabbits With Delayed-Onset SynostosiscraniosynostosisrabbitsTgf-beta 2neutralizing antibodiescraniofacial growthcoronal sutureObjectives: An overexpression of Tgf-beta 2 leads to calvarial hyperostosis and suture fusion in ...