TGFbeta signalling
2. Lewis KA, et al. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 2000;404(6776):411-414.3. Heldin CH, Moustakas A. Signaling Receptors for TGF-β Family Members. Cold Spring Harb Perspect Biol. 2016;8(8):a022053. Published 2016 Aug 1.4...
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[2] Vander Ark, A., Cao, J., & Li, X.. TGF-β receptors: In and beyond TGF-β signaling [J]. Cellular Signalling. 2018, 52, 112–120.
Signalling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, whichcatalysesthephosphorylationof the Type I receptor. Each class of ligand binds to a specific type II receptor[2].In mammals ...
TGF-β signalling prevents pancreat⁃ ic beta cell death after proliferation[J]. Cell Prolif, 2015,48(3):356- 362. doi: 10.1111/cpr.12183.TGF-βsignalling prevents pancreat-ic beta cell death after proliferation. Lei C,Zhou X,... Mao,Yuanyuan,Xixuan,... - 《Cell Proliferation》 被引...
In the well-understood classical TGF-beta signaling pathway, TGF-beta activates Smad signalling via its two cell surface receptors such as TbetaRII and ALK5/TbetaRI, leading to Smad-mediated transcriptional regulation. In addition, TGF-beta may also activate other signaling pathways like mitogen-...
The intracellular mechanism of transforming growth factor-beta (TGFbeta) signalling via kinase receptors and SMAD effectors is firmly established, but recent studies of human cardiovascular syndromes such as Marfan syndrome and pre-eclampsia have refocused attention on the importance of regulating the ava...
Betasuperfamilyofligandsinclude:Bonemorphogeneticproteins(BMPs),Growthanddifferentiationfactors(GDFs),Anti-müllerianhormone(AMH),Activin,NodalandTGFβ's[1].SignallingbeginswiththebindingofaTGFbetasuperfamilyligandtoaTGFbetatypeIIreceptor.ThetypeIIreceptorisaserine/threoninereceptorkinase,whichcatalysesthe...