6. Wang, F., et al., Tet protein function during Drosophila development.PLoS One, 2018. 13(1): p. e0190367. 7. Xie, T., Control of germline stem cell self-renewal and differentiation in the Drosophila ovary: concerted acti...
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Notably, TET2 is one of the most frequently mutated genes in hematological malignancies, including T cell lymphomas. However, murine models with deletion of TET2 do not exhibit T cell expansion, presumably due to redundancy with other members of the TET family of proteins. In order to gain ...
有学者推测,在胚胎发育过程中,TET酶高度表达并抑制分化,进一步推测HB的发生可能是由于分化早期肝脏分化受阻所致[52-53]。 近年来,借助于液体检验技术的快速发展,人们有能力在外周血检测到不同组织的细胞游离DNA(cell-free DNA,cfDNA),这对许多疾病的早期发现和及时...
CD4 + T细胞是人体免疫重要的一部分,其中辅助性T细胞17(T helper cell 17,Th17)和调节性T细胞(regulatory T cells,Treg)两个新近发现的CD4 + T细胞亚群在自身免疫疾病的发生发展中也起关键作用。Th17细胞能够引起自身免疫和炎性反应,而Treg细胞抑制疾病发生并维持免疫稳态;10～11易位蛋白(ten-eleven translocation,...
TET2/TET3 deficiency can lead to myeloid cell, B cell, and invariant natural killer T (iNKT) cell malignancies. In Tregs, TET2/TET3 deficiency in mice leads to hyperproliferation and inflammatory disease, with decreased expression of Treg-specific genes and increased expression of genes involved ...
抗体检测数据 (3) Created with Sketch. 图:1/3 Tet Repressor Antibody (PA1-29677) in WB Western Blot using Tet Repressor Polyclonal Antibody (Product # PA1-29677). Non-transfected (–) and transfected (+) 293T whole cell extracts (30 µg) were separated by 12% SDS-PAGE, and the memb...
the total cell number of the isolated spleens was comparable (Fig.1a). As control, we used CD4 cells from wild type sex and age matched mice (Supplementary Fig.2). The sortedTet2/3DKO CD4 cells consist of the total population of CD4 cells: naïve, memory and effector CD4+ T cells ...
TET3 has been shown to be involved in the demethylation of zygotic DNA before the first mitosis and has been suggested to be involved in the epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprogramming during animal...
We also identified two novel gene mutants of TET1 in 120 paired tumor/normal tissue specimens by DNA sequencing and found that TET1 E2082K mutant blocked the TET1〆nhanced cell migration. Our results showed that the downregulation of TET1 rescued the abnormally high levels of gene expression ...