Journal of the American Academy of Dermatology. 4:S129-33.Duvic M, Asanao A, Hager C, Mays S. The pathogenesis of psoriasis and the mechanism of action of tazarotene. J Am Acad Dermatol 1998;39:S129-32.The pathogenesis of psoriasis and the mechanism of action of tazarotene. Duvic, ...
Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acidreceptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. [3]. Tang-Liu DD, et al. Clinical pharmacokinetics and drug ...
[2]. Nagpal S, et al. Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acidreceptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. [3]. Tang-Liu DD, et al. Clinical p...
12.1 Mechanism of Action Tazarotene is a retinoid prodrug which is converted to its active form, the carboxylic acid of tazarotene, by deesterification. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα RARβ, and RAR γ, but shows relative selecti...
Trade name(s) TazoracTrade name(s)TazoracGeneric available NoGeneric availableNoDrug class RetinoidDrug classRetinoidMechanism of action Gene transcription after membrane receptor binding and intracellular transport; modulates abnormal epidermal keratinizationMechanism of actionGene transcription after membrane ...
[2]. Nagpal S, et al. Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acidreceptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. ...
The clinical significance of these findings is unknown.The mechanism of tazarotene action in the amelioration of fine wrinkling, facial mottled hypo- and hyperpigmentation, and benign facial lentigines is unknown. A histological study of tazarotene cream 0.1% applied in subjects with fine wrinkling and...
The pathogenesis of psoriasis and the mechanism of action of tazarotene[J].J Am Aced Dermatol,1998,(4 Pt 2):129-133.doi:10.1016/S0190-9622(98)70309-3.Duvic M, Asanao A, Hager C, Mays S. The pathogenesis of psoriasis and the mechanism of action of tazarotene. J Am Acad Dermatol ...
The exact molecular mechanism of action of topical tazarotene in the treatment of psoriasis has not been elucidated. However, the drug appears to modulate abnormal differentiation of keratinocytes, increased keratinocyte proliferation, and inflammation. Topical tazarotene is metabolized, in part, to taza...
Oral tazaroteneFocuses on the use of oral tazarotene in treating psoriasis. Side effects of the drug; Mechanism of action.Guttman, CherylDermatology Times