NF-r。B 信号转导通路与T AK I激酶在通路中的功能中文摘要转化生长因子激酶1(TAKl)是丝裂源激活蛋白激酶激酶激酶( MAP3K )家族成员之一, 在功能上位于丝裂源蛋白激酶( MAPK )和Ir,.B 激酶的上游。 在体内可以既可以被包括IL- 1在内的多种细胞因子激活, 参与机体的许多重要生理过程, 又可以通过与结合...
应用Western blotting和免疫荧光染色检测各组细胞中NF-κB通路表达水平和亚细胞定位.采用免疫沉淀技术检测调节CB2R对TAK1和TRAF6之间相互作用的影响以及TAK1泛素化水平.结果:免疫荧光染色显示小鼠脊髓损伤后1周损伤部位的CB2R表达量显著增加,CB2R在脊髓损伤后的差异性表达在小胶质细胞中最显著.BMS评分,水箱实验和步态...
遗传学专业优秀论文 NF-kB信号转导通路与TAK1激酶在通路中的功能 关键词:免疫遗传 蛋白激酶 信号转导 摘要:转化生长因子激酶1(TAK1)是丝裂源激活蛋白激酶激酶激酶(MAP3K)家族成员之一,在功能上位于丝裂源蛋白激酶(MAPK)和IKB激酶的上游。在体内可以既可以被包括IL-1在内的多种细胞因子激活,参与机体的许多重要生...
哈尔滨医科大学博士学位论文PhosphorylationofThrl78andThrl84onTAKlisrequiredforactivationofNFr,BandMAPKspathwayAbstractTransforminggrowthfacto
利用TAK1基因敲除MEF细胞,发现此二位点的磷酸化是IL-1诱导NFkB,JNK和p38信号通路激活所必需的.野生型TAK1的转入,可以恢复基因敲除细胞内IL-1通路的完整性.同时证明TRAF6也是通过TAK1激活NFkB途径.TAK1不但可以诱导IKKb的磷酸化,并且在NEMO多泛素化修饰过程中也是必不可少的.本研究证实Thr178和Thr184是两个可...
impairment of several intracellular signaling cascades and transcription factors including but not limited to NF-κB, MAPKs including p38 and JNK, and the antioxidant transcription factor Nrf2 has been implicated in increased ROS.5,12 Interestingly, recent studies have revealed that not all tissues or...
摘要: expression and TAK1/MEK and SMAD pathway activation induces pro-survival Mcl-1 expression. These data show that TGF-β-induced NFκB activation is through TAK1/MEK-mediated AKT activation, which is essential for TGF-β to support of osteoclast survival.关键词:...
The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes Mol Cell, 34 (5) (2009), pp. 591-602 View PDFView articleView in ScopusGoogle Scholar [41] Z. Tao, et al. p100/IkappaBdelta sequesters and inhibits NF-kappaB through kappa...
(AP-1). Stimulation of cells with cytokines and microbial pathogens results in the activation of TAK1, which subsequently activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases, culminating in the activation of NF-κB and AP-1, respectively. Recent studies ...
scription factors AP1 (activator protein 1) and NFkB are of major importance for OA, as they are increasingly activated under pathological conditions [24] and the expression of a number of genes important for the progression of OA, includ- ...