Purpose: Autoimmune hepatitis (AIH) is a chronic liver disorder, which is characterized by hepatocellular injury, and the development of cirrhosis associated with presence of variety of autoimmune serological markers. The disorder is felt to be immune mediated and a variety of immunosuppressive agents ...
Background: We studied the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy in pediatric patients with autoimmune hepatitis (AIH) who were intolerant or non-responders to standard therapy (corticosteroid and azathioprine). Patients and Methods: We performed a ...
To review studies that improve the diagnosis and treatment of autoimmune hepatitis and extend understanding of its pathogenic mechanisms.Black patients hav... Albert,J,Czaja - 《Current Opinion in Gastroenterology》 被引量: 6发表: 2008年 加载更多来源...
Key Points There is a cohort of patients with autoimmune hepatitis (AIH) who do not respond to standard therapy. Alternative treatment options for these patients have been explored, but outcomes have not been comprehensively examined. We report the use and efficacy of tacrolimus (TAC) in patients...
life-threatening hospitalisation disability congenital anomaly requires intervention to prevent permanent impairment or damage A 39-year-old woman developed inflammatory bowel disease (IBD) after receiving tacrolimus as immunosuppression, following liver transplantation due to cirrhosis and autoimmune hepatitis. ...
Tacrolimus has been used for treatment of selected human diseases, such as psoriasis, uveitis, corticosteroid-resistant nephrotic syndrome, recalcitrant pyoderma gangrenosum, new onset type 1 diabetes, autoimmune chronic active hepatitis, pediatric autoimmune enteropathy, Crohn's disease and atopic dermatitis...
Kappus, et al., Use of tacrolimus in the treatment of autoimmune hepatitis: a single centre experience, Alimentary Pharmacol. Ther. 34 (2011) 405e407.Tannous MM, Cheng J, Muniyappa K, et al. Use of tacrolimus in the treatment of autoimmune hepatitis: a single centre experience. Aliment ...
BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the ...
IntroductionStandard treatment of autoimmune hepatitis (AIH) consists of corticosteroids and azathioprine (AZA) and is effective in 80% of patients. There have been very few studies using tacrolimus as a novel second line treatment in patients with either steroid refractory or intolerant disease....
Investigations for viral hepatitis were negative but increasing liver stiffness measurements over time suggested progressive fibrosis. A liver biopsy at 24 months after initial transplantation suggested autoimmune hepatitis, but liver auto-antibodies were absent. On suspicion of liver toxicity, tacrolimus was...