为方便阅读，下文中的 大颗粒淋巴细胞白血病 已经自动替换为 TLGLL ，可 点此恢复原貌 ，或 使用备注方式展现 1 概述 TLGLL（Large granular lymphocytic leukemia，LGLL），1977年开始提出，是一种伴外周血大颗粒淋巴细胞增多的慢性中性粒细胞减少性临床综合征。1985年左右正式命名。其细胞...
Immunotherapies, specifically immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1(PD-L1), provided a significant advance in cancer treatment [1]. CAR-T cell therapy is a novel form of immunotherapy that employs genetic engineer...
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subset of ALL with poor clinical outcome compared to B-ALL. Therefore, to improve treatment, it is imperative to delineate the molecular blueprint of this disease. This review describes the central role that the Notch pathway...
T慢性淋巴细胞白血病(Large granular lymphocytic leukemia,LGLL),1977年开始提出,是一种伴外周血大颗粒淋巴细胞增多的慢性中性粒细胞减少性临床综合征。1985年左右正式命名。其细胞遗传学为克隆性异常,确定了其恶性肿瘤的性质。常用名还有:Tγ淋巴细胞增殖性疾病、伴颗粒淋巴细胞的淋巴细胞增殖性疾病、大颗粒淋巴细胞白血...
International Journal of Molecular Sciences Article Expansion of T Cells with Interleukin-21 for Adoptive Immunotherapy of Murine Mammary Carcinoma Christine K. Zoon 1,*, Wen Wan 2, Laura Graham 3 and Harry D. Bear 3 1 Department of Surgery, Virginia Commonwealth University Health System, Richmond...
Under optimal conditions these polyplexes reproducibly transfect >80% of the cells from a human T-cell leukemia cell line (Jurkat cells) at viabilities close to 90%. The agent also promotes pDNA uptake when simply added to a mixture of cells and pDNA. This constitutes a particular promising...
(Proviral Integration site for Moloney murine leukemia virus, a highly conserved serine/threonine protein kinase) or acyl-CoA acyltransferase] [177], P2XRs are, in principle, useful targets for enhancing T-lymphocyte cytotoxicity in the TME [178], although due to their widespread expression also ...
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. N. Engl. J. Med. 2018, 378, 439–448. [CrossRef] 3. Wu, L.; Wei, Q.; Brzostek, J.; Gascoigne, N.R.J. Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells. ...
In the past few years, CAR T cells targeting Cluster of Differentiation 19 (CD19) have achieved impressive outcomes in the treatment of patients with relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL) [7–9]. Although CD19 CAR T cell treatment of R/R B-NHL has been less ...