Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7DS+4Ato G)in one CYP11B1allele and R448Hin exon 8in the other. Dumic K,Wilson R,Thanasawat P,et al. European Journal of Pediatrics . 2010...
11β-羟化类固醇脱氢酶2 1. Apparent mineralocorticoid excess(AME) is an autosomal recessive disease caused by deficiency of the enzyme of11beta-hydroxysteroid dehydrogenase type 2(11β-HSD2). 表观盐皮质类固醇激素过多综合征(AME)是由于11β-羟化类固醇脱氢酶2(11-βHSD2)缺陷所致的常染色体隐性遗传性...
Wang XL et al (2000) Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1). Endocrinology 141:3587–3594 Wang ZN, Bassett M, Rainey WE (2001) Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase. J Mol Endocrinol 27:255–25...
we measuredsteroidogenic acute regulatory protein(star),cytochrome p450 17a1(cyp17a1) and11-beta-hydroxylase(cyp11β) transcript levels in testis tissue. StAR facilitates the rapid, gonadotropin-stimulated translocation of cholesterol to the inner mitochondrial...
D. 11-beta-hydroxylase3-17-21-11 Mineralocorticoid synthesis (aldosterone) location Zona glomerulosa of adrenal cortexSelectivity is due to aldosterone synthase solely being expressed in the ZG Mineralocorticoid synthesis (aldosterone) pathway 1. Pregnenolone2. Progesterone3. 11-deoxycorticosterone4. ...
Brautbar, C., Rosier, A., Landau, H., Cohen, I., Nelken, D., Cohen, T., Levine, L. S. and New, M I. (1979). No linkage between HLA and congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.N. Engl. J. Med.,300, 205 ...
In this review, the authors describe: (1) the different types of hormone receptors, on the and two types inside the cell, the and GR (mineralo- and glucoreceptors); (2) the synthesis of the hormones with the decisive role of the final enzymes, 11 beta-hydroxylase and -synthetase; (3...
1) 21-hydroxylase deficiency leading to increased synthesis of 17-hydroxy-progesterone and androgens; 2) 11β-hydroxylase deficiency leading to deoxycortisol and deoxycorticosterone accumulation and attendant hypertension; 3) 3β-hydroxysteroid dehydrogenase deficiency resulting in accumulation of pregnenolone an...
11. Bafl F, Saka N, Darendeliler F, Tuzlali S, Ilhan R, Bundak R, Günöz H. Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency. J Pediatr Endocrinol Metabol 2000 Jun;13(6):663-7. 12. Kim YT, Kim SW, Yoon BS, Kim...
英文别名: steroid 15-beta-hydroxylase 中文名: 中文别名: CBNumber: CB71383899 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 0 steroid 15-beta-hydroxylase化学性质 安全信息steroid 15-beta-hydroxylase性质、用途与生产工艺 steroid 15-beta-hydroxylase 上下游产品信息 上游原料 ...