This new therapy seeks to reset the immune system by killing it off using high-dose chemotherapy, then restarting it using the patient's own blood stem cells. Doctors harvest and preserve the patient's stem cells before treatment, and re-implant them following chemotherapy. "Because many of th...
Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury and immune disorders. In this review, we...
Mesenchymal stromal/stem cells (MSCs) are one of the most frequently used stem cells in cellular therapy trials based on their immunomodulation, tissue regeneration, and protective functions [1,2,3]. Previously, exogenous-infused MSCs were thought to exert their protective effects by migrating to d...
Stem cell therapies are a type of cell therapy in which the cells used are either stem cells (as in the case of bone marrow transplantation) or are derived from stem cells, as is this case with some stem cell therapies that are currently being investigated for their therapeutic potential in...
Currently, there is only one drug for the disease, and it slows the progression but does not halt it, said the study. Not only do the brain stem cells from primary progressive MS patients look older, they also act older, the team found. ...
MSC-like cells were first discovered by Friedenstein in 1970 in guinea-pig bone marrow (BM) [16]. However multiple cell types in the BM led to controversy in selecting a specific name for these cells. Later, the ISCT termed these cells multipotent mesenchymalstromalcells based on specific pro...
There is no single, universally agreed-upon set of guidelines for defining sex and gender. We offer the following guidance: Sex and gender-based analyses (SGBA) should be integrated into research design when research involves or pertains to humans, animals or eukaryotic cells. This should be do...
There was no evidence of cardiac regeneration by the infused MSC or endogenous cardiac stem cells based on lack of evidence for cardiac myocytes being derived from replicating cells. These results indicate that stem cell transplantation may have significant beneficial effects on injured organ function ...
A preliminary study on the use of stem cells obtained from a patient's own adipose tissue in the treatment of multiple sclerosis (MS) has shown promising results. The three case studies, described in BioMed Central's open accessJournal of Translational Medicinesupport further clinical evaluation of...
We find that cell spreading, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) are all enhanced in cells cultured in gels with faster relaxation. Strikingly, MSCs form a mineralized, collagen-1-rich matrix similar to bone in rapidly relaxing hydrogels with an initial ...