The past decade has seen tremendous advances in the treatment of myeloma, centered around 2 classes of drugs — proteasome inhibitors like bortezomib and carfilzomib, and immunomodulatory drugs like thalidomide and lenalidomide, explained Jacalyn Rosenblatt, MD, hematologist and assistant professor of medic...
Cells used for transplant in patients derived from the expansion of the BI-0194-008 cell line performed at ‘Laboratorio di Terapia Cellulare e Genica Stefano Verri - ASST - Monza, Ospedale San Gerardo’ under GMP conditions with standard operating procedures (Supplementary Fig.2). The starting m...
This can be explained by the higher incidence of severe GVHD among recipients of non-HLA-identical transplants. Our findings also demonstrated that haemorrhagic complications - particularly bleeding from the GI tract - markedly increase patient mortality. An ongoing, multi-centre, randomised, double-...
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a potentially curative treatment for patients with high-risk hematological malignancies encompassing acute myeloid leukemia, high-risk myelodysplastic syndromes (MDS), and lymphoid leukemia1,2,3,4. It is well-established that the gut bacteri...
When should stem cell clinical trials not be performed? As already explained, there are many different approaches for stem cell therapies. The objectives of clinical trials are drug safety and effectiveness evaluation. In personalized medicine, the stem cells are obtained from the patients themselves;...
The citrate dose of the cell drug is increased more than twice as much as the standard protocol. Such a scheme of introduction is explained by the fact that in the short-term treatment it is necessary to increase the dose to obtain a stable result of up to 220% on average. For example...
Nonetheless, there was a functional improvement, which might be explained by other processes, such as a paracrine induction of regeneration, rather than incorporation and differentiation [20]. Diabetes and metabolic syndrome Both BMSCs and ADSCs have been extensively investigated in diabetic animals. ...
as described in a previous study22. The meta-regression was univariate rather than multivariate and we calculated adjusted R2values to explain the proportion of the observed variability in the observed effect size for a group of experiments explained by variation in the independent variable in questio...
108and that multiple populations within the same tumor can contain cells exhibiting cancer stem cell (CSC) activity.109This may in part be explained by technical differences,110but it is also possible that the CSC phenotype may be elicited by different genetic programs, all converging on a ...
This rapid action cannot be fully explained by improving β cell function and insulin resistance. The liver maintains normal blood glucose levels by regulating glycogen metabolism and gluconeogenesis. A 24-h period after ADSC infusion, T2DM rat models’ liver enzyme levels increased related to ...