This first-in-human, phase 1 study assessed the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of SLN124 (1.0, 3.0, and 4.5 mg/kg) in healthy volunteers. Twenty-four participants were randomized in three sequential cohorts of eight subjects, each to ...
In the single dose study evaluating healthy volunteers with high Lp(a), participants who received SLN360 (300 mg and 600 mg doses) saw median maximal Lp(a) reductions of 96% and 98%, respectively. SLN124 for hematological diseases Sites are open for enrollment in the SLN124 phase...