Biol. 18,136–141.Slide to the Left and Slide to the Right:Motor Coordination in NeuronsMartin Harterink1and Casper C. Hoogenraad1,*1Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands*Correspondence: c.hoogenraad@uu.nlhttp://dx.doi.org/...
Coordination model: motor activity is regulated while bound to the cargo. Bottom left: model based on work by Fu and Holzbaur (2013), which is a combination of coordination and recruitment models. Bottom right: the JIP-motor complex could serve as an interaction hub for various signaling and...
Cha Cha now y"all! Last time we"re getting funky! To the right now! To the left! Take it back now y"all! One hop this time! One hop this time! Right foot two stomps! Left foot two stomps! Slide to the left! Slide to the right! Criss-Cross! Criss-Cross! Cha Cha real smooth!
Right foot let's stop Left foot let's stop Cha-cha now y'all Now it's time to get funky To the right now To the left Take it back now y'all One hop this time One hop this time Right foot two stops Left foot two stops Slide to the left Slide to the right Criss cross Criss...
To the right now to the left Take it back now ya'll 1 hop this time 1 hop this time Right foot 2 stomps left foot 2 stomps Slide to the left slide to the right Criscross criscross Cha Cha real smooth Let's go to work To the left take it back now ya'll 2 hops...
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Molecular motors employ specific adaptor proteins to dock on transport cargos. Reporting in The Journal of Cell Biology, Fu and Holzbaur (2013) show that the adaptor JNK interacting protein 1 (JIP1) binds kinesin-1 and dynactin and controls bidirectional axonal amyloid precursor protein trafficking...