Background: SIRP伪-Fc-CD40L is a hexameric, bi-functional fusion protein consisting of SIRP伪 linked to CD40L via an inert Fc linker. This molecule competitively inhibits CD47 to enhance tumor cell phagocytosis and activates CD40 to increase antigen processing and cross-presentation by antigen ...
SIRPα-Fc-CD40L is a hexameric, bi-functional fusion protein consisting of SIRPα (binding affinity to CD47 is 0.628 nM) linked to CD40L (binding affinity to CD40 is 4.74 nM) through an Fc linker protein.1 By augmenting antigen processing and promoting antigen presenting cell (APC) maturation...