MTHFRChechenCircassianMethylenetetrahydrofolate reductase (MTHFR) C677T single nucleotide polymorphism is a major inherited risk factor of venous thromboembolism. We sought to determine its prevalence in genetically isolated populations of Chechens and Circassians in Jordan. The MTHFR C677T mutation was ...
Objective to establish a simple and practical method for detecting the MTHFR gene C677T mutation so as to investigate MTHFR genotypes in the healthy elder and Vascular Dementia (VD). 目的建立一种简便、实用的检测亚甲基四氢叶酸还原酶(MTHFR)等位基因C677 T点突变的方法,并初步观察部分健康老人和老年...
To actively transport many of its proteins to extracytoplasmic compartments such as the periplasm and outer membrane, E. 4. 28kb 目的研究导致大肠埃希菌dna回旋酶a亚单位的基因变异耐喹诺酮类药物的机制。 OBJECTIVE to study the mutation in DNA gyrase a of Escherichia coli resistante to quinolone...
Both of these two algorithms adopt single-gene mutation evolution strategies that suit for high dimensional optimization,which can not only compute usual definite integral for any functions,but . 两种算法都采用适用于高维优化问题的单基因突变进化策略,使得该算法不但能计算通常意义下任意函数的定积分,而且...
Epidemiological evidence suggests that thrombophilic factors, including male sex, non-O blood type, MTHFRnt677TT mutation, factor V Leiden G1691A mutation, and prothrombin G20210A polymorphism, may contribute to the progression of fibrosis and occurrence
95% CI=1.06–5.34).9Supplementation with folic orfolinic acidreduced the risk of toxicity-related discontinuation of MTX treatment in both patients with and without the mutation.9Urano et al examined the relation between genotypes or haplotypes concerning polymorphisms of theMTHFRgene and MTX efficacy...
2003). Nevertheless, we have provided a more detailed description of within population differences that was not captured in any of the previous studies. Our results are in agreement with a previous study investigating the prevalence of MTHFR 677TT genotype in different regions in Mexico in which ...
Results: Based on the results of the PCR test of the MTHFR gene, the incidence rate of mutation in the healthy allele was 44.6% and in the mutant allele was 27.9% of the total study population. Conclusion: In this study, it was discovered that an increase in cholesterol levels...
In conclusion, the MTHFR 677TT or 1298CC genotypes are much rarer in Africans than in Caucasians. The 677TT low frequency may be related to the high effect of this mutation on homocysteine metabolism in the environmental conditions of this African region.Adjalla...
Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J. Biol. Chem. 1995, 270, 4640–4649. [Google Scholar] [CrossRef] [PubMed] [Green Version] Rouquier, S.; Lowe, J.B.; Kelly, R.J.; Fertitta, A.L.; Lennon, G.G.; Giorgi,...