Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome sequ
and will the query basically join the Dept&Emp tables together in the same way ? or i should always initiate a .ToList() to force the query execution for (Single , SingleOrDefault , First, FirstOrDefault ) ? second question, if i am searching using a primary key (DeptID in my case)...
Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to this article.Data availability Sequencing data have been deposited at ArrayExpress under the following accession numbers: E-MTAB-11488, E-MTAB-11452 and E-MTAB-11467. Code availabilit...
(CAM) to control access to the shared memory instead of a linked-list[26,27]. Cells are stored in therandom access memory(RAM) and tags (consisting of destination information and a sequence number) used for referring cells are stored in theCAM. Using this approach, memory space requirements...
Use nb show and nb browse to view code snippets with automatic syntax highlighting and use nb edit to open in your editor. The clip plugin can also be used to create notes from clipboard content. Piping, --title <title>, --tags <tag-list>, --content <content>, and content passed in...
If you have both an AMD GPUandan NVIDIA GPU in your machine, then you may need to qualify which one you want used, by passing either--gpu amdor--gpu nvidia. In the event that GPU support couldn't be compiled and dynamically linked on the fly for any reason, llamafile will fall bac...
Current methods for analyzing single-cell datasets have relied primarily on static gene expression measurements to characterize the molecular state of individual cells. However, capturing temporal changes in cell state is crucial for the interpretation o
Co-expression networks have been a useful tool for functional genomics, providing important clues about the cellular and biochemical mechanisms that are active in normal and disease processes. However, co-expression analysis is often treated as a black box with results being hard to trace to their...
The protected pointer consists of three words, comprising of: a) a pointer to a memory location, such as a node in linked list, together with b) an ABA avoidance sequence number, and combined together with a third word containing c) a specially crafted hash code derived from the pointer ...
We complemented these differential activity analyses by examining genes that were differentially expressed in the tumor-specific macrophage population, which were only be identified by VIPER-based protein activity clustering (Figure 1C). Once a finer-grain cluster structure was revealed, several genes ...