It can be found in cancer cells, urine, blood or other body fluid that are expressed due to cancer cell growth. The two fundamental signalling pathways appear to be focused towards the breast cancer are the PI3K/AKT pathway and the JUN/MAPK pathway. The risk of breast cancer is not the ...
This Review highlights the complexity and context-dependent roles of both β-catenin-dependent and β-catenin-independent WNT signalling pathways in cancer, as well as some of the ways in which WNT signalling might be targeted therapeutically. Since the
In addition, we examined MAP kinases as potential targets of retinoid signalling in human breast cancer cells and demonstrated that retinoids repress AP1-responsive gene expression by inhibiting MKK6/p38 and mainly MEK/ERK signalling pathways. On the contrary, the JNK-dependent pathway was not ...
pathways are upregulated in prostate cancer following androgen-deprivation therapy (ADT). Furthermore, upregulation of PARP activity is essential for the survival of prostate cancer cells and we demonstrate a synthetic lethality between ADT and PARP inhibition in vivo. Our data suggest that ADT can...
Sonic hedgehog and Wnt/β-catenin pathways mediate curcumin inhibition of breast cancer stem cells Cancer stem cells (CSCs) play essential role in the progression of many tumors. Wnt/尾-catenin pathway is crucial in maintaining the stemness of CSCs. ()-E... X Li,X Wang,C Xie,... - An...
This study aimed to identify clinically targetable pathways that are aberrantly active downstream of E-cadherin loss in ILC. Using a combination of reverse-phase protein array (RPPA) analyses, mRNA sequencing, conditioned medium growth assays and CRISPR/Cas9-based knock-out experiments, we demonstrate...
Pietras RJ, Marquez-Garban DC: Membrane-associated estrogen receptor signaling pathways in human cancers. Clin Cancer Res. 2007, 13 (16): 4672-4676. 10.1158/1078-0432.CCR-07-1373. Article CAS PubMed Google Scholar Song RX, Zhang Z, Chen Y, Bao Y, Santen RJ: Estrogen signaling via a...
Characterization of Fibronectin-mediated FAK Signaling Pathways in Lung Cancer Cell Migration and Invasion Focal adhesion kinase (FAK) is overexpressed in a variety of cancers such as breast, colon, prostate, ovary and lung.However, the mechanism by which extrac... MENG,Xiang-ning,LEE,... - ...
Prostate cancer is the most common cancer in males inwestern countries and breast cancer is the most prevalent cancer in women in India. It has long been appreciated that multiple signaling pathways coexist within the cell during cancer development. Many examples have been presented in which these...
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. Here we describe quantitative mass-spectrometry-based proteomic and phosphoproteomic