Over the last decade, significant progress has been made in defining the anabolic and catabolic signaling pathways that control skeletal muscle mass through the regulation of protein synthesis and degradation. The purpose of this review is to briefly describe known and emerging signaling pathways ...
important role in preserving hibernating muscle mass in bears. We found that the expression of structural proteins (Mybpc1, Tnni3, Myh7b) was increased, while expression of the actin-severing protein gelsolin (Gsn) was decreased. This is consistent with transcriptional changes that favor muscle-...
Fig. 1. Conserved Signaling Pathways associated to longevity suggests energy control plays a vital role in longevity and aging: The nutrient sensing pathways, namely IIS (insulin/insulin-like growth factor 1 pathway) and TOR (target-of- rapamycin), are conserved across species. Genetic downregulatio...
To confirm these findings by an independent approach, and identify additional proteins that bind plakoglobin, we transfected mouse tibialis anterior (TA) muscle with a plasmid encoding 6His-plakoglobin and isolated bound proteins with a Nickel column (Fig.2a). Mass spectrometry analysis identified most...
SUMMARY: The maintenance of muscle mass requires a delicate balance between catabolic factors and anabolic factors. These signals inversely modulate the activity of several key regulatory pathways including the phosphoinositide-3 kinase/AKT and nuclear factor kappa B systems, which control the ...
The HOMA2-IR-associated dmCpGs were enriched in genes associated with insulin and AMPK signalling pathways, as well as muscle development and tissue homeostasis. The IR-associated methylation signal was attenuated after adjustment for ALMi or BMI, suggesting that muscle mass and body composition make...
4A-K). Therefore, these findings suggest that HME can enhance MRFs activity, promoting muscle regeneration, differentiation and increasing muscle mass and function. Conversely, after 24 h of BME treatment, we observed increased expression levels of PGC-1α, Myf5, and Myod1, but no significant ...
5, a reduction in dosage of either Traf6 or ben resulted in a significant decrease in the number of melanotic masses per animal, compared to that of the SMN RNAi-only control. In summary, these observations show that Toll, IMD, and TNF-Eiger signaling pathways are disrupted following the ...
healing and muscle differentiation [5,9]. We also confirmed contrasting effects between normal and abnormal cells according to the type of gas used [6]. However, the underlying molecular mechanisms remain unclear. In this study, we found that LP stimulation activated the angiogenesis-signaling ...
out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function. The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development. In this manuscript, we wil...