the Signaling Pathways Project (SPP), that enhances the FAIR status of public cell signaling ‘omics datasets along three dimensions. Firstly, SPP encompasses datasets involving genetic
Integrated mining of public transcriptomic and ChIP-Seq datasets has the potential to illuminate facets of mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP), which incorporates stable community ...
325,527 Besides, increased PKA activity inhibits membrane-bound p-Akt-Ser473 via PI3K/PIP3-mediated translocation of Akt to the membrane, which may promote mTOR/CREB and FoxO signaling pathways.528 Second, GLP-1-producing neurons in the NTS directly project to other nucleus associated with food...
Wnt signaling has been shown to be activated in HSCs upon liver injury and the increased expression of many components of different Wnt pathways including Wnt ligands, Frizzled receptors, LRP5/6 co-receptor and β-catenin have been documented during HSCs trans-differentiation. Furthermore, studies ...
of SMF-treated cells coupled with analysis of the microarray data by the Ingenuity Pathway Analysis software tool [21–23] verified that anticipated transcriptional changes – qualitatively consistent with the impact of altered Ca2+ flux or membrane domain fluidity on signaling pathways – did occur....
Code related to the manuscriptInferring signaling pathways with probabilistic programming(Merrell & Gitter, 2020) Bioinformatics, 36:Supplement_2, i822–i830. This repository contains the following: SSPS: A method that infers relationships between variables using time series data. ...
1999. We will refer to pathways such as the one that positions the spindle in EMS, which utilize GSK-3 but are independent of transcription, as Wnt spindle orientation pathways. Although many Wnt signaling components have been identified that participate in spindle orientation, the role of the ...
We thank Dr. Rong Sun (Nantong University) for his kind help in the manuscript editing and revision. Funding This work was supported by grants from the National Natural Science Foundation of China (81903033) and the project of the Science & Technology Department of Sichuan Province (2018JY0568...
Evolutionarily conserved signaling pathways are essential for early embryogenesis, and reducing or abolishing their activity leads to characteristic developmental defects. Classification of phenotypic defects can identify the underlying signaling mechani
35. Native cell signaling pathways are optimized by evolution to precisely regulate cellular behavior. Hijacking a signaling node that is shared by multiple pathways thus enables us to add a novel function to an operational system, such as expression of IL-12 concomitantly with T-cell line ...